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Copyright ? 2011 John Wiley & Sons, Ltd. ""What's already known about this http://www.selleckchem.com/products/VX-770.html topic? Birth weight (BW) prediction is an important part of obstetric management. It is a key determinant of perinatal outcome with poor outcomes resulting from delivering macrosomic neonates or growth-restricted neonates. Maternal obesity, assessed by BMI, has been associated with an increased risk of fetal macrosomia, neonatal adiposity and metabolic syndrome. There is a paucity of data in the literature on maternal body composition and its relationship to BW. What does this study add? First trimester maternal body composition was assessed accurately and objectively by bioelectrical impedance analysis and correlated to BW. We accurately identify which maternal body composition parameters including visceral fat and waist circumference independently influence BW. We also explore customised centiles and population based centiles at birth. Potentially, this study may help to identify a modifiable risk factor to reduce the incidence of macrosomia and neonatal adiposity. ""The aim of this study was to investigate the association of the first trimester screening variables nuchal translucency (NT), pregnancy associated plasma protein (PAPP-A), and free beta-human chorionic gonadotrophin http://www.selleckchem.com/products/Imatinib-Mesylate.html (��hCG) and birth weight, with a focus on the prediction of macrosomia. The database of our Fetal Medicine Unit was searched for all singleton pregnancies, who underwent first trimester Down syndrome screening. Live born infants born at term without chromosomal or structural defects from non-diabetic mothers constituted the study population. Birth weight percentiles were corrected for gestational age at delivery, parity, and gender. Macrosomia was defined http://www.selleck.cn/products/mi-773-sar405838.html as birth weight ��95th centile. We included 6503 fetuses. Multivariate analysis demonstrated that birth weight centile was positively correlated with NT multiples of the median (MoM), PAPP-A MoM, and maternal body mass index, and it was negatively correlated with smoking. An NT ��95th centile was present in 315 fetuses (4.8%). Although median birth weight centile was not significantly different between cases with NT ��95th centile and those 95th centile was more common (11% vs 7%) in the presence of NT ��95th centile. Pregnancy associated plasma protein was elevated (��95th centile) in 303 cases (7.9%). Median birth weight was higher (P56 vs P51, P?=?0.03) in case of elevated PAPP-A compared with PAPP-A