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It was concluded that nicotine in cigarettes might increase the risk of depression by affecting the neurotransmitters that play a role in the development of depression, or nicotine might exacerbate the depressive symptoms as a result of smoking more cigarettes to eliminate the depressive symptoms and distress.[41] The prevalence of depression was found to be significantly higher http://www.selleckchem.com/products/BEZ235.html in individuals with a history of any chronic diseases than those without (P? http://www.selleck.cn/products/gsk-j4-hcl.html with multiple chronic diseases and associated functional disability than those without.[29] Several other studies also reported a higher prevalence of depression in individuals with chronic disease.[24, 36, 38] The prevalence of depression was not different between individuals with a family history of depression and those without (P?>?0.05). However, in his book chapter on depression in older people, Colin http://www.selleckchem.com/products/byl719.html Hughes emphasized positive family history as a risk factor.[33] This discrepancy of the results might be a result of the limited number of participants in the present study. Although genetic inheritance is important in many chronic diseases, it is impossible to show such a cause�Ceffect relationship in a cross-sectional study. In a case�Ccontrol study from Malaysia, it has been reported that positive family history of depression was associated with a fourfold increase in the risk of depression.[43] The prevalence of depression was significantly higher among elderly people living alone compared with those living in a nuclear family or patriarchal family structure (P?