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Methods: Our database was searched for SPM in CLL patients (pts) treated within four prospective phase II/III trials. The trials evaluated fludarabine (F) versus F + cyclophosphamide (FC) [CLL4], chlorambucil (CLB) versus F [CLL5], FC without or with http://www.selleckchem.com/products/jq1.html rituximab (FCR) [CLL8], and bendamustine + R (BR) [CLL2M]. Results: Follow-up data of 1458 pts were evaluated. Median observation times for CLL4, CLL5, CLL8 and CLL2M were 107, 70, 69 and 37?months for pts alive respectively. 270 SPM were observed in 239 pts (16.4%). Median times from start of treatment to onset of SPM were 50, 37, 22 and 19?months for CLL4, CLL5, CLL8 and CLL2M respectively. SPM were observed at rates of 21.3% for F, 17.7% for FC, 15.5% for CLB, 13.1% for FCR, and 11.1% for BR (p?=?0.03). In therapy combinations with R versus without R, the occurrence of SPM was 12.7 versus 18.5% (p?=?0.004). However, considering different observation times in Kaplan Meier estimation the difference was not confirmed with a SPM-free survival at 4.5?years of 89.2 versus 84.7 (p?=?0.1). Age >65?years showed a significant influence on SPM (p? http://www.selleck.cn/products/AP24534.html ratio showed a 1.23 fold increased risk of solid tumours in comparison with the age matched general population from the German cancer registry. 75 pts (5.1%) developed a Richter Syndrome. Most common hematologic neoplasia (N?=?38) were AML/MDS (50%), indolent B-NHL (24%) and Burkitt/ALL (13%). Non-melanoma skin tumours (N?=?36) and hematologic neoplasia did not correlate http://www.selleckchem.com/products/Rapamycin.html with type of first-line treatment. Conclusion: CLL pts treated by chemotherapies or chemoimmunotherapies have a surprisingly high risk of developing SPM above 10%. Longer follow-up and additional analyses are needed to determine the factors that might contribute to development of SPM. FOCUS ON���� SESSION: NOVEL MONOCLONAL ANTIBODIES 038 NOVEL PI3K-d INHIBITORS DEMONSTRATEDMARKED CYTOTOXICITY IN T-CELL LYMPHOMA MODELS AND WERE SYNERGISTIC WITH A NOVEL ANTI-CD20 MAB, UBLITUXIMAB, IN LYMPHOMA MODELS C. Deng,1 R. Rodriguez,1 P. Sportelli,2 H. Miskin,2 S. Vakkalanka,3 S. Viswanadha,4 O. O'Connor.1 1Center for Lymphoid Malignancies, Columbia University Medical Center, New York, USA; 2Clinical Development, TG Therapeutics, Inc., New York, USA; 3Clinical Development, Rhizen Pharmaceuticals, Inc., La Chaux de Fonds, Switzerland; 4Drug Discovery, Incozen Therapeutics, Hyderabad, India. Introduction: The delta (��) isoform of PI3K is highly expressed in cells of hematopoietic origin and strongly upregulated in various hematologic malignancies. Recently, novel agents targeting PI3K-�� have been developed, with pharmacologic and pharmacodynamic features distinct from GS-1101 (CAL-101).