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, Somers, NY). Overall, 10,685 potential donors consented to donate UCB to our facility: 1830, 3806, and 5049 in 2004, 2005, and 2006 (Table?1). During the whole http://www.selleckchem.com/products/obeticholic-acid.html study period, 6280 (58.8%) donations were ineligible and the exclusion rates in 2004, 2005, and 2006 were 93.1, 48.4, and 54.1%, respectively. We excluded 612 donations from pregnant women before delivery, 133 UCB units during delivery, 80 units before processing, 5010 units during processing, and 421 units after freezing. There were 24 UCB units with unknown reasons of ineligibility. The exclusion in all intended donations for each phase decreased gradually. The most common phases of exclusion were during processing (79.8% of all exclusions), before collection (9.7%), and after freezing (6.7%). The number and proportion of reasons for exclusion before collection, during delivery, and during the processing are presented in Table?2. The association among the reasons of UCB exclusion and the time periods was significant (p? http://www.selleckchem.com/products/Adriamycin.html and most were because of maternal fever or sickness. In addition, 157 (25.7%) were ineligible on the basis of obstetric factors, whereas the most common reason was premature rupture of membrane more than 24 hours earlier; 124 (20.3%) were discarded because of the artificial errors, 53 (8.7%) due to holiday reason, and 36 (5.9%) by cancellation. The annual occurrence rates for each reason varied significantly, except for the maternal medical problems (Table?2). For example, the rate of discarded UCB units because of the artificial errors before collection decreased to 5.7% in 2006, which was lower than that in 2004 (26.1%). A similar pattern was observed for reasons including obstetric problems and cancellation. At the time during delivery, the major reason for an ineligibility to donate was due to problems pertaining to the infants (86.5%) such as meconium stain and prematurity, whereas the other problems included those pertaining to the placenta and umbilical cord (13.5%). The rate of discarded UCB pertaining to the infant during delivery was http://www.selleck.cn/products/sch772984.html lower in 2006 than that before 2006. At the time before processing, the exclusion was stable except for a high number in 2005. This increase resulted from bad weather (e.g., typhoon) in that year. The most common phase for deferral of UCB was at the time during processing. In particular, the most common reason was low weight (60.9%), followed by low cell count (38.7%). These two reasons were also the leading causes of exclusion in the overall cohort (48.6 and 30.9%, respectively). The exclusion rate due to the low unit weight decreased significantly in 2006 but the percentage of low cell count increased annually (p?