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��It also explored potential reasons for that, although it didn't identify any definitively. In the study by Stark et al, baseline QoL data were collected just before treatment started and on the first day of each 3-week chemotherapy cycle for 4 months. Following that, data were collected every 6 weeks during the next 8 months, and every 3 months during year 2. The 58 items on the ovarian cancer module of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Ovarian Cancer Module (EORTC OV28 and Core 30) were used. Of note, QoL data were not collected at the time of disease progression, but there is a scheduled QoL survey for patients still alive at 3 years that will be reported in the future. All 1528 women in the study were http://www.selleckchem.com/products/Cyclopamine.html asked to fill out QoL questionnaires. At baseline, 90% of women in http://www.selleck.cn/products/gsk126.html both arms provided completed data. Reasons for a missing questionnaire were recorded so it was known whether it was patient or investigator dependent. At 54 weeks, 388 women (51%) in the control arm and 502 women (66%) in the bevacizumab arm provided data (33% of women in the control arm and 19% of women in the bevacizumab arm had developed disease progression or died, and therefore no QoL data were obtained). During the 18 weeks chemotherapy was administered, the mean global QoL of women in both groups improved by 7.2 points. At the end of chemotherapy, there was a difference of 5 points in the mean global QOL scores. At week 54, there was a difference of 6.4 points; both favored the control arm and both were significant (P? http://www.selleckchem.com/products/BI-2536.html Cancer Center in New York City, adds, ��The threshold for clinical significance in quality-of-life studies is always a challenge. It is equally true that determining the threshold for clinical significance is also challenging when considering PFS/OS benefits, as well as toxicity for agents in oncology.�� He adds that the study points to the importance of including QOL as a study endpoint, particularly when the primary efficacy endpoints yield modest results. Placing patients on maintenance therapy, even with modest toxicity, carries a measurable detriment to QoL,�� Dr. Stark notes. ��This raises a pertinent question: if the gain seen is in length of cancer control, not in length of life, is this in the patient's best interest? The findings by Dr.