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Choi et al. (2004) defined PE based on hypertension (BP greater than http://www.selleckchem.com/products/Everolimus(RAD001).html systolic BP 140 mmHg or diastolic BP 90 mmHg) and more than 1000 mg/l (or 2+ dipstick) of proteinuria in random urine determinations after the 20th week of pregnancy. In the study of Roberts et al. (2004), PE was defined as a blood pressure of at least 140/90 mmHg on two separate occasions 6 h apart, and at least 1+ proteinuria on dipstick after 34 weeks of gestation, while early onset PE was the development of hypertension and proteinuria for the first time prior to the 34th week of gestation. In all other studies, the cases were well-defined following the criteria as described earlier. We performed the main analysis and a sensitivity analysis on the basis of case definitions. Controls were normotensive pregnant women. In most of the studies, the genotype frequencies were in agreement with HWE expectation. Under the assumption of HWE, genotype frequencies in unrelated controls from a general population should be randomly distributed on the basis of the observed allelic frequencies. However, deviations from HWE were discovered in controls of four studies (Ward et al., 1993; Bashford et al., 2001; Tempfer et al., 2004; Aggarwal et al., 2011) for the M235T polymorphism (Supplementary Table S1) and two for the T174M polymorphism (L��vesque et al., 2004; Knyrim et al., 2008) (Table S2). But these studies should not be excluded because there are no other grounds for doubting the quality of these studies. Therefore, in this study, we preformed analyses including and excluding the two highly significant (P http://www.selleckchem.com/products/PD-0332991.html Aggarwal et al., 2011). There were 12 studies in Caucasians (Ward et al., 1993; Guo et al., 1997; Morgan et al., 1999; Curnow et al., 2000; Procopciuc et al., 2002; Bouba et al., 2003; Zhang et al., 2003; L��vesque et al., 2004; Tempfer et al., 2004; Benedetto et al., 2007; Jenkins et al., 2008; Knyrim et al., 2008), 10 in Mongolians (Ward et al., 1993; Guo et al., 1997; Romi et al., 1997; Kobashi et al., 1999; Li et al., 1999; Suzuki http://www.selleck.cn/products/bmn-673.html et al., 1999; Choi et al., 2004; Kim et al., 2004; Huang et al., 2007; Song et al., 2007), five in Africans (Curnow et al., 2000; Roberts et al., 2004; Hillermann et al., 2005; Wang et al., 2006; Jenkins et al., 2008) and four in other ethnic populations (Bashford et al., 2001; Dissanayake et al., 2009; Aggarwal et al., 2010; Aggarwal et al., 2011) which we put together in a miscellaneous group (Table S1). There were significant differences in the frequency of 235T allele between Caucasians (0.424), Mongolians (0.711) and Africans (0.869) (all pairwise P