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""Sutureless thyroid surgery utilizing thermal sealing is now well established. However, incremental advances in technology still require formal clinical evaluation in order to ensure that added technology does not compromise http://www.selleckchem.com/products/poziotinib-hm781-36b.html safety. In this study, we compared a new thermal sealing device incorporating a tissue divider (LigaSure Small Jaw) with the device we have previously reported for use in total thyroidectomy (LigaSure Precise). A cohort study was undertaken of 872 total thyroidectomies over a 2-year period. Patients were selected for each group on the basis of device availability within four institutions and outcomes were obtained from a prospectively maintained database. Small Jaw was used in 399 cases and Precise in 473. No significant differences between patient demographics (sex, age), operation indication or pathology were found. Significantly more Small Jaw operations were performed in private versus public hospitals (P http://www.selleckchem.com/products/ganetespib-sta-9090.html while providing the added benefit of a significant reduction in operative times. ""Background:? Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis typically resulting in hypothyroidism. In itself, HT is not an indication for surgery but the co-existence of http://www.selleck.cn/products/cobimetinib-gdc-0973-rg7420.html thyroid nodular disease creates diagnostic and management difficulties. Indications for thyroidectomy include risk of malignancy and pressure symptoms. While fine needle aspirate cytology is effective in the diagnosis of thyroid lesions, in HT there is increased diagnostic uncertainty. This study aimed to document the results of cytology and the rate of malignancy in HT. Methods:? Data were analysed for the period 1996�C2009. All patients who underwent thyroidectomy and had a formal histological diagnosis of HT were included and compared with a control population who underwent thyroidectomy but did not have HT. In both groups, patient demographics, clinical parameters, cytology findings, operative procedure and final histology were reviewed. Results:? One hundred and twelve patients had histologically proven HT, with a significant female preponderance compared with controls (P= 0.002). There were no significant differences between cases and controls for type of procedure or preoperative examination findings. Incidence of hypothyroidism was increased: 17 patients (15.2% versus 1.6%; P