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The thrombin clotting time (TCT) was performed using the STA? -Thrombin kit (Diagnostica STAGO). This assay was modified to incorporate a thrombin concentration of six Natioanl Institutes of Health (NIH) units/ml, instead of 1��5?NIH units/ml in order to afford greater sensitivity to therapeutic UFH. All automated assays were performed on the STA-R? coagulation analyser (Diagnostica STAGO). Statistical software package Stata, Release 10.0 (STATA Corporation, http://www.selleckchem.com/products/Rapamycin.html College station, TX, USA) was utilised for data processing and analysis. Numerical variables were presented as means and standard deviations. A P-value of http://www.selleckchem.com/products/MG132.html blood samples collected at least threes times post-UFH administration; 69% of patients had blood samples collected at all four time-points post UFH administration. Table?I summarizes discrete results for the APTT, anti-Xa, TCT and protamine titration assays across all sample collection time-points. Despite http://www.selleck.cn/products/Bleomycin-sulfate.html modifying the upper limits of detection of the APTT and TCT assays, the majority of results were greater than the maximum recordable limit of 999?s. All baseline APTT results were within the relevant age-related reference ranges for the institution. Specimens collected at a mean time post-UFH bolus of 17?��?6?min were associated with APTT and TCT results above the limits of detection for the analyser in 89% and 69% of samples respectively. For samples collected 47?��?8?min following UFH bolus, the proportion of APTT and TCT results without endpoint remained at 60% and 42% respectively. All results presented in Table?I reflect the mean?��?SD of recordable APTT and TCT results only. Table?II presents the correlation coefficients between measures of UFH effect (APTT, anti-Xa, anti-IIa, TCT) and concentration (protamine titration). Agreement between all measures of UFH effect and protamine titration was found to be poor (r2?0��11�C0��59). Table?III presents the mean APTT and therapeutic range corresponding to an anti-Xa assay of 0��35�C0��7?iu/ml and a protamine titration range of 0��2�C0��4?iu/ml respectively. APTT results corresponding to a protamine titration assay of 0��2�C0��4?iu/ml and an anti-Xa assay of 0��35�C0��?iu/ml were both associated with an upper APTT limit in excess of 180?s in this population of children.