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Representative photomicrographs of the developing kidney in the late first trimester (50?��?2 days gestation), early second trimester (80?��?2 days gestation), late second trimester (100?��?2 days gestation), early third trimester (120?��?2 days gestation), and near term (150?��?2 days gestation) are shown in Fig. 1. Mean kidney weights, lengths, and widths are shown in Table 1. Fetal weight increased nearly 100-fold from the late first trimester (5.27?��?1.01 g) to the third trimester (505.25?��?26.11 g) while individual kidney weight increased more than 200-fold (0.02?��?0.01 g vs. 1.58?��?0.13 g). No significant differences between the measures and weights http://en.wikipedia.org/wiki/Diglyceride of the right and left kidneys were detected (data not shown). The ratio of individual kidney weight to fetal body weight increased from the late first trimester (2.86?��?0.82) to a maximum in the second trimester (4.01?��?0.07) (P? http://www.selleckchem.com/products/AZD0530.html (Fig. 2A). Exhaustive sectioning and tabulation of counted sections provided a means to compare the isector counting approach with the ��gold standard' stereological approach (physical disector-fractionator) (Pakkenberg and Gundersen, 1988) for counting the number of homogeneous structures. The estimated number of glomeruli per kidney across gestation was similar and highly correlated (correlation coefficient?=?0.99) between both stereological approaches. The number of glomeruli per kidney increased more than 28-fold from the late first trimester http://www.selleckchem.com/products/GDC-0941.html (1.1 �� 103) to the early second trimester (3.2 �� 104) (P?