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Conclusions: Circumferential membranous GPC3 immunoreactivity in HCC indicates poorer prognosis particularly in patients with HCV infection. ""Morocco is one of low to intermediate endemic areas for hepatitis B virus (HBV) infection, but no reports have been published on Occult HBV infection (OBI). To determine the prevalence of OBI http://www.selleckchem.com/products/dabrafenib-gsk2118436.html and its clinical impact among patients with cryptogenic and HCV-related chronic liver disease in Morocco. A total of 152 HBsAg-negative patients (60 patients with cryptogenic hepatitis and 92 HCV carriers) were enrolled in this study. Sera collected from all patients were tested for anti-HBc and anti-HBs antibodies. OBI was assessed in serum and liver tissue samples using highly sensitive PCR assays targeting Surface, X and core regions of the HBV genome and confirmed by Southern blot hybridization. A high rate of anti-HBc positivity was found among patients with HCV infection (57/92, 61.95%) compared to those with cryptogenic hepatitis (24/60, 40%) (P?=?0.034). A high prevalence of OBI was found among patients with HCV infection (42/92, 45.65%) compared to those with cryptogenic hepatitis (17/60, 28.3%) (P?=?0.013). In both groups, the prevalence of OBI increased in parallel with advancing stage of liver disease (��2?=?6.73; P?=?0.0095). The highest proportion of OBI was reached among HCV-related HCC cases (62.5%). Multivariate Cox regression analysis revealed that older age (��56?years), positivity for anti-HBc and presence of OBI were independent risk factors for the development of HCC in HCV-infected http://www.selleckchem.com/products/sch772984.html patients. This study helps to understand the current status of OBI and its impact on the severity of liver disease in Moroccan patients. ""The role of quantitative hepatitis B surface antigen (HBsAg) after hepatitis B e-antigen (HBeAg) seroclearance http://www.selleck.cn/products/z-vad-fmk.html is not well defined. To determine the role of HBsAg levels in predicting significant viremia and hepatitis flares after HBeAg seroclearance. A total of 228 chronic hepatitis B patients with spontaneous HBeAg seroclearance were included. Patients were followed up regularly at 3�C6 monthly intervals with routine liver biochemistry and hepatitis B serology. Levels of HBV DNA and HBsAg were measured at yearly intervals for up to 5?years after HBeAg seroclearance. The median log HBsAg and HBV DNA level after HBeAg seroclearance was 3.52?IU/ml and 4.13?IU/ ml respectively, with no significant correlation observed between them (P?=?0.572). The HBV DNA at HBeAg seroclearance was 4.13 log IU/ml, compared with 3.12 log IU/ml after 5?years (P?