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, 2010]. Against this background, we sought to examine the WM pathways in POMS patients as compared to their age- and disease duration-matched AOMS counterparts, and to determine whether this population of patients has a unique ability for preservation of WM microstructure that may help us understand the age of onset influence on the evolution http://www.selleckchem.com/products/obeticholic-acid.html of disease progression. In this study, a group of POMS patients (n = 16) were analyzed against two cohorts of AOMS patients matched individually for age (AOA, n = 23) and for disease duration (AOD, n = 22). The DTI exams from the POMS group and two AOMS comparator groups were obtained from a preexisting http://www.selleck.cn/products/LY294002.html dataset, as part of a >800 MS patients prospective clinical surveillance study [Yeh et al., 2009]. For this study, the following inclusion criteria were applied: presence of a 3T MRI scan, DTI sequence acquired with identical scanning protocol and relapsing-remitting (RR) disease course [Lublin and Reingold, 1996]. In total, 61 subjects were randomly selected among the entire dataset who fulfilled these criteria (Table 1). The POMS group consisted of 16 adults who had age of onset 18 and http://www.selleckchem.com/products/Adriamycin.html each orthogonal plane of 50 mT/m (zoom mode) using 8-channel head coil. All scans were prescribed parallel to the subcallosal line in an axial-oblique orientation. One average was used for all sequences. All sequences were obtained as follows, except as noted below: 256 �� 192 matrix (freq �� phase), field-of-view (FOV) of 25.6 cm �� 19.2 cm (256 �� 256 matrix with Phase FOV = 0.75), for an in-plane resolution of 1 mm �� 1 mm, with 48 3-mm slices collected with no gap.