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""QT interval prolongation is frequent in cirrhosis, and stressful conditions could further prolong QT. We aimed to test this hypothesis and, if it proved correct, to assess its prognostic meaning. We reviewed the clinical records of 70 consecutive cirrhotic and 40 non-cirrhotic patients with acute gastrointestinal bleeding. All patients had been evaluated before bleeding (T0) and were re-evaluated at the time of bleeding (T1) and 6?weeks afterwards (T2). QT corrected by heart rate (QTc) lengthened at T1, http://www.selleck.cn/products/Everolimus(RAD001).html returning towards baseline values at T2 (mean?��?SEM; from 415.9?��?4.3 to 453.4?��?4.3 to 422.2?��?5.7?ms, P? http://www.selleckchem.com/products/ch5424802.html 32.1% for those with one risk factor and 70.6% for those with both (P? http://www.selleckchem.com/products/azd9291.html drug users with CHC were divided into three groups: (A) patients on a substitution programme; (B) active users; and (C) past IDUs. Patients were treated according to the standard of care and followed by a specialist team. Results: A total of 175 patients (mean age 39.4��8.8) were included. One hundred and forty-four (65%) were adherent to therapy (completing treatment and 6 months of follow-up). Twenty-two patients (36%) discontinued because of side effects, 28 (46%) discontinued on their own and 11 (18%) completed treatment but did not present at follow-up. Of 142 patients with available treatment outcome, 99 (69.7%) achieved a sustained virological response (SVR), with no differences among the study groups. Patients with genotypes 2�C3 and those who completed the treatment schedule had 2.78-fold (95% CI: 1.3�C5.8) and 6.4-fold (95% CI: 2.6�C15.6) higher probability of achieving SVR.