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The prognostic index provides more accurate prediction of both TTF and OS. To our knowledge this is the first prognostic model in CLL to reach the C-statistic threshold (c > 0.70) necessary to have utility at the level of the individual. 056 OBINUTUZUMAB (GA101)+CHLORAMBUCIL (CLB) OR RITUXIMAB (R) + CLB VERSUS CLB ALONE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA (CLL) AND PRE-EXISTING MEDICAL CONDITIONS (COMORBIDITIES): FINAL STAGE 1 RESULTS OF THE CLL11 (BO21004) PHASE 3 TRIAL M. Hallek,1 K. Fischer,1 K. Humphrey,2 E. Asikanius,3 R. Busch,4 A. Engelke,1 C. M. Wendtner,5 O. Samoylova,6 T. Chagorova,7 M. S. Dilhuydy,8 J. De La http://www.selleck.cn/products/AP24534.html Serna,9 T. Illmer,10 S. Opat,11 C. Owen,12 K. A. Kreuzer,13 A. W. Langerak,14 M. Ritgen,15 S. Stilgenbauer,16 M. Wenger,3 V. Goede.1 1German CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, http://www.selleckchem.com/products/Rapamycin.html University Hospital Cologne, Cologne, Germany; 2Medical Affairs, F. Hoffmann-La Roche Ltd, Welwyn, UK; 3Medical Affairs, F. Hoffmann-La Roche Ltd, Basel, Switzerland; 4Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany; 5Department of Hematology and Oncology, Schwabing Hospital Munich, Munich, Germany; 6Hematology, Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod, Russian Federation; 7Oncology, Penza Regional Oncology Dispensary, Penza, Russian Federation; 8Hematologie Clinique, Hopital De Haut Leveque, Pessac, France; 9Servicio De Hematologia, Hospital Univ. 12 De Octubre, Madrid, Spain; 10Department of Medicine, Private Oncology Practice, Dresden, Germany; 11Haematology, Monash Medical Center, Clayton, Australia; 12Department of Medicine, Tom Baker Cancer Centre, Calgary, Canada; 13Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany; 14Department of Immunology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands; 15Medical Department http://www.selleckchem.com/products/jq1.html II, University of Schleswig Holstein, City Hospital Kiel, Kiel, Germany; 16Department of Internal Medicine III, University of Ulm, Ulm, Germany. Introduction: Chemoimmunotherapy (CIT) is standard of care in young and physically fit patients (pts) with CLL. Development of CIT for older and less fit CLL pts is ongoing, but data from phase 3 trials are sparse. CLL11 is the largest trial to evaluate 3 treatments in previously untreated CLL pts with comorbidities: Clb alone, GA101 + Clb (GClb), R + Clb (RClb). The final analysis of CLL11 stage 1 efficacy and safety results is presented here. Methods: Treatment-na?ve CLL pts with a Cumulative Illness Rating Scale (CIRS) total score >6 and/or an estimated creatinine clearance (CrCl)