I had a major flareup with my rash on my face and the muscle and joint pain also. What is so strange is I have been having trouble even taking my premarin pills that I have been taking since my total hysterectomy back in 1991,and I had to totally quit taking it because of it causing a severe rash on my face and the joint pain getting worse also. Well, the last few days things got worse,and worse and I decided to try taking 1/2 of some of the Premarin tablets again just to see what would happen. I got the usual flareups,but for some strange reason the burning in my legs eased up and I have allot more energy,but it is a toss up between the bad flareups from taking it ,or the benefits. All I know to do is just try to not take as much as I was in the begining which was 1 tablet a day, and just try maybe 1 tablet a week. I don't know what this is,but I'm really sinsitive to allot of medications and hormones have really gotten where they make me sick and cause major flare ups. After my Insurance was refused at that last doctor,I'm now going to have to try and search for a doctor who will accept it.