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A P-value? http://en.wikipedia.org/wiki/MRIP and body mass index) [21]. As our sample size was not designed for such analyses, we compared various alternative models to provide appropriate statistical power for mediation tests. Poisson regression analysis of the total number of CV (TCV) events during the trial with adjustment for baseline age, gender and CV score was shown to provide a power of at least 0.75 when testing a maximum of three simultaneous mediators. We first assessed univariate mediating models for http://www.selleckchem.com/products/pf-06463922.html each mediator to eliminate any indirect effect of http://www.selleckchem.com/products/AZD1152-HQPA.html group were slightly older than those receiving placebo (63.6?��?9.6 vs. 59.1?��?11.0?years), had a more extensive CV disease history (1.17 vs. 0.92) and were less often smokers. All other characteristics were comparable between the treatment groups (Table?1). Of the 390 included patients, 277 (71%) completed the HOME trial (Fig.?1). Those who did and did not complete the study did not differ with respect to duration of diabetes, previous occurrence or severity of CV disease, age or weight. The mean dose in the metformin group was 2050?mg during the trial. There was no difference between the groups in the use of acetylsalicylic acid, antihypertensive drugs or statins. Metformin treatment was associated with less weight gain (mean difference, ?3.07?kg; range, ?3.85 to ?2.28?kg; P?