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This work was supported by a Queensland University of Technology, Institute of Health and Biomedical Innovation Early Career Research Grant. The assistance of Keratoconus Australia with subject recruitment is also gratefully acknowledged. ""To examine the circadian intraocular pressure (IOP) patterns in healthy subjects, in primary open angle and normal tension glaucoma (POAG; NTG) using a contact lens sensor (CLS; Sensimed Triggerfish, Lausanne, Switzerland). This was an observational, nonrandomized study. Ten healthy subjects (Group 1, 10 eyes) and 20 glaucomatous patients [20 eyes, 10 with POAG (Group 2) and 10 with NTG (Group http://www.selleck.cn/products/Imatinib(STI571).html 3)] were enrolled. All patients were controlled with prostaglandin analogues. The 24-hr IOP pattern was the main outcome. The morning (6AM�C11AM), afternoon/evening (noon-11PM) and night (midnight-5AM) subperiod patterns, peaks and prolonged peaks (>1?hr) were secondary outcomes. Mean 24-hr IOP pattern showed a nocturnal acrophase in all groups. Patterns were significantly different among groups (p?=?0.02), with highest nocturnal IOP values in POAG. Prolonged peaks were more common in patients with glaucoma (70%) than in healthy subjects (33.3%) (p? http://www.selleckchem.com/products/AZD6244.html the morning versus afternoon/evening (p?=?0.019 and p?=?0.035, Bonferroni correction), morning versus night (p?=?0.005 and p? http://www.selleckchem.com/products/SP600125.html in tear fluid in humans following eye drop administration. Concentration of dexamethasone was measured by mass spectrometry. One drop of DexNP was instilled into one eye. Tear fluid was sampled with microcapillary pipettes at seven time-points after drop instillation. Control eyes received Maxidex? (dexamethasone). The same procedure was performed for dorzolamide with DorzNP and Trusopt?. Six subjects were included in each group. The peak concentration (��g/ml?��?standard deviation) of dexamethasone for DexNP eye drops (636.6?��?399.1) was up to 19-fold higher than with Maxidex? (39.3?��?18.9) (p?