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PPI were inappropriately not prescribed in 20 patients (48.8% of patients with an indication for PPI treatment). Regression analysis showed that the total number of non-PPI prescribed drugs (OR 1.08; 95%CI 1.01�C1.15) and a higher Charlson Comorbidity Index (OR 1.08; 95%CI 1.001�C1.16) were independently associated with inappropriate PPI overprescribing. Potential http://www.selleck.cn/products/gsk-j4-hcl.html drug�Cdrug interactions were found in 75 patients (22.8% of the study population), mainly in patients with PPI overprescribing. Inappropriate PPI prescribing is common in frail older hospitalized patients, and might increase the risk of drug�Cdrug interactions. Polypharmacy and comorbidity were independently associated with inappropriate PPI prescribing in this group. Geriatr Gerontol Int 2013; 13: 1002�C1009. ""Increasing age and a diagnosis of dementia both dramatically increase the risk of serious osteoporosis-related sequela. We sought to examine the factors associated with osteoporosis treatment, in relation to dementia diagnosis, in older adults with osteoporosis. This was a population-based, retrospective, nested, case�Ccontrol study utilizing administrative healthcare data from British Columbia, Canada. Community-based individuals aged ��65 years with an osteoporosis diagnosis and continuous enrolment in the provinces' drug plan between 1991 and 2007 were eligible for inclusion. A multivariate logistic regression model was assembled to examine the relationship between dementia diagnosis, age, sex, other comorbidity, http://www.selleckchem.com/products/BEZ235.html residence and osteoporosis medication dispensation. Almost half of the total osteoporosis cohort (n?=?39?452) were http://www.selleckchem.com/products/byl719.html dispensed an osteoporosis medication during the study period. Individuals with no dementia diagnosis were dispensed a medication significantly more often than those with a diagnosis of dementia (P?