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However, the relevance of isolated 25-OHD measurement without PTH may overestimate vitamin D depletion (because of seasonal or recent vitamin D deficiency) and the need for pharmacologic vitamin D supplementation. Further studies are needed to determine the clinical implications of an isolated 25-OHD measurement to assess VDN. Disclosures: Nayana Parikh, http://www.selleckchem.com/products/Adriamycin.html None. SA0295 Serum Levels of Cathepsin K and Bone Turnover Markers are Decreased in Patients with Type 2 Diabetes.Pedro Rozas*1, Rebeca Reyes2, Antonia Garc��a-Mart��n3, Maria Dolores Perez-Avil��s3, Mariela Vasavsky3, Manuel Munoz-Torres4. 1Hospital General, Spain, 2Bone Metabolic Unit., Spain, 3Bone Metabolic Unit. Endocrinology Division. San Cecilio University Hospital., Spain, 4University Hospital, Spain Background: Studies of bone resorption in diabetes are limited, and the results are conflicting. Aim: To analyse serum levels of bone turnover markers (BTM), cathepsin K, PTH-i and 25 OH vitamin D in patients with type 2 diabetes mellitus (T2DM) and the relationship with bone mineral density (BMD). To compare BTM and cathepsin K levels between T2DM and controls. Patients and methods: Case-Control study including 133 subjects, 78 patients with T2DM and 55 healthy controls. Lumbar spine and femoral BMD were measured by dual X-Ray absorptiometry (Hologic QDR 4500). We measured: bone alkaline phosphatase (b-ALP) (OCTEIATMIDS Ltd Boldon UK), osteocalcin (OC) (DiaSorin, Stillwater, Minnesota USA; tartrate resistant acid phosphatase (TRAP) (Bone TRAP ? Assay IDS Ltd); CTX (Elecsys �� Cross-Laps, Roche Diagnostics SL, Barcelona, Spain); Serum cathepsin http://www.selleckchem.com/products/obeticholic-acid.html K levels by ELISA (Biomedica Medizinprodukte GhbH & Co KG Wien, Austria). PTH-i (Intact PTH, Roche Diagnostics SL); 25 OH vitamin D (25-Hydroxyvitamin D 125I RIA DiaSorin). Results: Mean age was 56,7 �� 6,8 yr (57.8 http://www.selleck.cn/products/sch772984.html �� 6.4 and 55,1 �� 7,1 in T2DM and control group respectively; p=0.024). Among the T2DM patients (n=78), 47.2% were females (n=35) and 52.8% males (n=43). Serumlevels of bone resorption markers were lower in T2DM compared with controls (TRAP: T2DM 1.39 �� 0.99 UI/l vs controls 1.85 �� 0.81 UI/l, p