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For patients with diabetes, CABG had a rate of repeat revascularization less than half that of PCI (CABG 12.9% versus PCI 28.0%, P = 0.001). This contributed to the lower rate of MACCE in diabetic patients (CABG 22.9% versus PCI 37.0%, P = 0.002). Four-year SYNTAX follow-up results were presented at the European Association for Cardio-thoracic Surgeons in Lisbon, October 2011. These showed continuing divergence of the primary endpoint. CABG was superior to PCI for MACCE (CABG 23.6% versus PCI 33.5%, P http://www.selleck.cn/products/cobimetinib-gdc-0973-rg7420.html versus PCI 8.3%, P http://www.selleckchem.com/products/ganetespib-sta-9090.html assessment of graft/vessel patency. However, graft occlusion was documented in 26 out of 827 (3.14%) CABG patients and stent thrombosis in 36 out of 885 (4.07%) PCI patients. In 10 out of 36 patients, stent thrombosis resulted in fatal MI (no fatal MI for CABG graft occlusion). Nine of the 36 stent thromboses occurred after 1 year �C five were on dual anti-platelet therapy and four on aspirin therapy alone. Two of those on aspirin had ceased their clopidogrel in the 2�C4 weeks preceding stent thrombosis. The biggest criticism of surgery in the SYNTAX trial was the increased rate of stroke �C 2.2% versus 0.6% in the first year (P = 0.003).[32] The details of timing of these strokes have not been published, but have been presented by the authors (M. Mack, unpublished, 2009). Three of the 19 strokes (0.3%) in the CABG arm occurred preoperatively (no preoperative strokes in PCI) but are included because results were analysed by intention to treat. Nine strokes (1%) occurred in the period http://www.selleckchem.com/products/poziotinib-hm781-36b.html between the procedure and 30 days inclusive (2 strokes (0.2%) in the PCI arm), and 7 strokes (0.8%) between 30 days and 1 year (3 strokes (0.3%) in the PCI arm). The higher rate of dual anti-platelet therapy after PCI compared with CABG may have influenced the rate of stroke occurring in the early post-operative period. The rate of stroke for OPCAB was 0.7% (1 stroke in 134 patients). The difference did not reach significance by the third year of follow-up (CABG 3.4% versus PCI 2.0%, P = 0.07). In the New York Registry, PCI showed a significant survival advantage for two- and three-vessel disease after CABG at 8 years in 7235 matched patients (CABG 78.0% versus PCI 71.2%, HR: 0.68; 95% CI: 0.64�C0.74; P