Interesting question. I would take it when it is your "daytime". If your day starts at 11 am, I would take it then. As far as sleeping, I found Benedryl has kept me able to sleep. It is non-addicting and easy to tolerate.

Sorry. I see you go to bed at 11 am so I wouldn't take it then. Take it when your day starts. That way you can sleep.

Ok, i just remember back in feburary when i first started taking 60mg of pred they told me to take it in the morning. Well i took it during my morning at 8pm. After about 4 or 5 days I started to get awfully dizzy and nauseas. I wonder if it was bacause my body was trying to get use to the new meds or if it was that I was taking it in the eve rather than the morn. Told my dermatologist and she said no matter my sleep pattern I should continue to take in the am before 11am. Right now I am down to 17 1/2, perscribed by rheumy. So dont know how much of an affect if any if i were to change the time i take it.

Krissytin, I know the body produces cortisol from the adrenal glands in the morning hours between 4 am - 10 am.

I think having a sleep problem on any dosage of prednisone is a problem. Prednisone disrupts electrical signaling in the brain and this may be what is causing you to wake up. You could try a sleeping aid but sleeping pills never worked for me.

I regularly wake up between 2 am till 4 am. I always have some ache or pain which gets in the way of sleeping. I also know it is the electrical signal changes in the brain that keep me from sleeping. I get to do a lot of thinking during my waking hours, and I find the thinking to be productive.

Talk to your doctor about the sleeping problem. I have learned to live with my sleep disruptions. Good Luck!

Hi. I would do ad Alexis suggests. It makes sense. You could check with your doctor, you can't be the only person taking Pred and working nights. Best wishes. Autumm

I never thought of the impact of your natural cortisol production. I would talk to your doctor. As Autumn says, you can't be the only one in this situation.