Polymyositis & Dermatomyositis Support Group

Polymyositis (PM) is a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis. The inflammation is predominantly of the endomysium in polymyositis, whereas dermatomyositis is characterized by primarily perimysial inflammation.

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amberhere 09/22/2014

Hi all, just wondering if anyone feels "yukky" the same day as taking MTX and the next day feel really sleepy? After these 2 days I feel relatively back to "normal".

trpt1 09/22/2014

Hi Amberhere, When I was taking MTX, I always experienced the MTX hangover that you mention. I thought the MTX served me well for the three years that I took the med.

I now take Cellcept daily with no yucky hangovers. I do get sleepy, but that is due to either my liver or heart. I do not get sleepy every day.

Be sure to mention getting sleepy and all side effects to your doctor. You might not think getting sleepy is important, but it is good to mention and have the doctor check just in case.

Best Wishes for success on your MTX.

lexisgirl 09/22/2014

I take MTX injections. I take them right before bed. The next day I am sleepy and groggy. I have found it is better the longer I take it. I allow myself to sleep in as long as I want and take a nap if I want. Since I usually do my injection on Saturday night, Sunday is my couch day. I don't plan anything and just take it as it comes.

Do mention it to your doctor. I do think it is as expected.

Krissytin 09/22/2014

I felt terrible after every time I took it and I did take it with a meal to avoid that feeling but it didn't work. I used to take it before work, bad idea haha. I felt nauses for days. I tried to wait it out and see if my body would be able to adjust to it, but it didnt. So I told my doctor and switched to cellcept.

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