I haven't really experienced that. I do get lower back aches but it is when I stand or walk much. My doctor said it is because of my huge prednisone belly throwing me out of wack! Perhaps call your doctor and let them know your concern.

Hi Amberhere. I have no experience with this. Just a call to your GP might be a good move if its not any better today. Autumm

Hi Amberhere, These DMARDs all have something that is crummy with each of them. If you look up Drugs.com then you can go over MTX side effects. Do discuss any discomfort with your doctor.

I would get dehydrated with MTX too. I would take my med on a Friday night so that I would have the weekend to feel better before going back to work on Monday. I did have different crummy feelings and mild nausea too. All of my bad feelings did go away after I got used to the med. I stayed on MTX for three years. It does take time to get used to any DMARD. I started on 17.5mg of MTX and I later moved up to 20mg my second year. In my case, I found that for me it is better to start at a lower dosage and move up the dosage slowly to get used to the med.

I have been on MTX 20 mg for months now and have not noticed any pain associated with taking it. Some mild nausea, fatigue the day after. Though I am mostly used to it now. I would put a call in to your Dr. just to be sure since each person is different.

Thanks for all your comments, I will check on Drugs.com - the pain seems to be wearing off a little now so I'm hoping it may have been just a trapped nerve. I try not to get panicky but so aware of things that may go wrong. Will have to learn not to panic so much.

Hi Amberhere. Glad you are feeling better. Its normal to worry like this at the beginning. Hope it all goes well. Autumm