Hi! I haven't and had never heard of the Wylie protocol until you mentioned it, but I want to respond mostly because this group has been so quiet lately. I had my uterus and ovaries removed at 40, and I never went through the horrible symptoms of menopause I'd read about. Maybe because I'm thin and kind of a fitness freak? The only type of hormone I use is a vaginal cream.

Thanks for the reply. The wiley protocol uses bio identical hormones that take you through a cycle much like the cycle of a younger woman. Natural Progesterone has protective effects against Colon cancer which I have a strong family history of. So I am sure that I want to include progesterone in my hrt. I am 41 now and just got my results a month ago. I am also thin and enjoy an active life and am. I am not thrilled at the prospect of menopause!

It really sounds interesting. I have a family history of colon cancer too, and I forgot to say I'm MSH2 positive just like you. I also had severe endometriosis and had ovarian cancer at 40, so they didn't want to put me on estrogen. Don't get me wrong, I wasn't thrilled about going into sudden menopause. It's just that this was 16 3/4 years ago, and I've been fine - no major bone density loss, no hot flashes & no problems with sex (hope it's okay to say that here, lol). They've learned a lot in the last 16 3/4 years. Good luck!

Hi again, I have been reading medical studies like crazy. The one thing I am sure of is that estrogen dominance is the enemy of all lynch syndrome cancers. Even without ovaries you can be at risk for cancer due to unnaposed estrogen. Women and men produce and store estrogen in their fat. We also eat estrogens in our food. Estrogen unnaposed by bio identical progestone increases risks for virtually all lynch associated cancers (colon, ovarian, brain, uterine) and new studies on unnaposed estrogen keep coming. Women don't produce any progesterone (needed to counteract estrogen dominance) after they stop ovulating. That's years before completion of menopause, and positively correlated with the mean age of onset for lynch reproductive cancers. Interestingly men produce protective progesterone in good quantities sometimes into their sixties. And then it doesn't just stop (like it does with women) but is not enough to counteract their rising estrogen levels. Maybe that's why lynch men don't have the reproductive cancers in their prostate until way later than lynch women. Anyhow, investigate for yourselves but I would advise all lynch carriers, men And women to keep their weight down and use a natural progesterone cream, or if you are not comfortable with something non-prescription then ask your doctor to prescribe prometrium.

Curious what information you've found since your post. I'm also Msh2 positive and am scheduled for hysterectomy next month (age 38). 2 cousins have already had surgery and neither did any HRT but my GYN was shocked by that. Trying to determine what route to take and runnning out of time! Thanks!