For me it did almost immediately and stayed for the first week and a half. After that, they went away (headaches). I'm glad you didn't suffer from insomnia. I think each person is different, though.

One thing I wish I would have done was keep a journal. You might want to think about that. I'm sure newbies will be asking you about your experiences in the near future.

I can't say enough great things about LDN. I've been on it a year and it really has improved my life! Hang in there, Brian, and update us on your progress. :)

Thanks, I did start writing in my DS journal to keep track. I just hope if I', not getting the side effects I am still going to get the good effects. I know it can take 3 months to start seeing the good results so I'm definitely sticking with it.

should be after 10PM (9pm Standard Time), so unless you're in Indiana or Arizona, can you take it a little bit later?

Larry, I'm on PST. Does the time you take it matter so much as where you are in your sleep cycle when it kicks in?

doesn't matter where you are, if you move your clock one hour ahead, the Earth doesn't, so 10pm during Daylight Saving is 9PM STANDARD time. The recommendation is After 9pm Standard time, so 10pm Daylight Saving Time during these months.

I take it between midnight and 1am local time, all the time, nothing to do with my sleeping. I often don't go to sleep until sunrise. When I used to work 12-8am, I was taking it upon waking.

Larry, I'm still a little confused about why the timing issue is so important. I have been staying up a little later and taking it closer to 11:00, but sometimes I'm tired before that. If I wait and take it in the middle of the night will that be ok? Could you explain more? I hear some people take it in the morning and don't have to worry about any insomnia. Is it not working as well in those people?

it's only important if it means the difference of working well, stopping progression, and works best for you. Some people with other diseases find they can take it any time they like, and they feel it works.

People with MS who started taking it 9pm in the winter used to complain that it's just no longer working.... when do they take it? 9pm? what time is it April-October? 8pm Standard. They started taking it an hour later, aka 9pm Standard/10pm Daylight and it worked again. So we assume that it is important, for those it don't work for, noticeably, during DST days.

I take mine near Midnight every day, used to work 12-8am all the time, so I was just waking up.