I have tried some various treatments for my edema in my legs. The most important of course is daily wrapping, without support they tend to swell up. I have been using Eucerna Calming Cream on my legs and they look less red and I have not had any sigificant blisters on my left leg. I have been taking the herb Horse Chestnut which is suppost to have some diaretic effect on the legs. Kaiser website says to use for short term and may cause damage to kidneys so I need to check on this more.