Three days of usage and the results are astounding...Baby has had no "accidents", (she was peeing on my chair and bed.) Also she always defecated besides the litter box and has not since i started "treatment." BUT the biggest surprise is Smokie...she was always very skittish and the change in her is tremendous...she is affectionate, settled and follows me around like she never did before...she still whacks at Tucker and Paleface, who are about 3 times bigger than her, which is ok...that her personality!!! Don't want to lose that!!!