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Lungs of 3-week-old wild-type Balb/c mice were exposed by pharyngeal aspiration nine times over 3?weeks to DEP at 1.2 or 6.0?mg/kg body weight, house dust mite (HDM) at 0.8, 1.2 or 6.0?mg/kg of DEP in combination with HDM, or the same volume (50?��L) of 0.9% sterile saline. In young mice, exposure to 1.2?mg/kg of DEP caused http://www.selleckchem.com/products/Docetaxel(Taxotere).html no detectable lung inflammation, but 6.0?mg/kg of DEP induced neutrophilic influx. Compared to HDM or DEP alone, mice exposed to either dose of DEP together with HDM demonstrated increased allergen-specific IgE, lung inflammation, airway hyperreactivity, goblet cell metaplasia, Th2/Th17 cytokines, dendritic cells, activated T cells, effector T cells, and IL-17pos and IL-13pos/IL-17Apos T effector cells. In young mice, co-exposure to DEP and HDM together exacerbated allergic sensitization and induced key characteristics of more severe asthma, including IL-17A, IL-17pos and IL-13pos/IL-17Apos T effector cells. While exposure to 1.2?mg/kg DEP alone caused no detectable changes, it did exacerbate allergic sensitization and asthma characteristics to a similar degree as a five-fold higher dose of DEP. This study demonstrates that exposure to DEP, even at a dose that alone causes no inflammation, exacerbates allergic http://en.wikipedia.org/wiki/Vatalanib asthma in young animals and suggests the importance of preventive measures to reduce the exposure of children to traffic related air pollution. ""Liu T-H, Lin Y-R, Yang K-C, Tsai Y-G, Fu Y-C, Wu T-K, Wu H-P. Significant factors associated with severity and outcome of an initial episode of acute urticaria in children. Pediatr Allergy Immunol 2010: 21: 1043�C1051. ? 2010 John Wiley & Sons A/S The aim of this study was to determine the predictive factors of severity and duration of an initial episode http://www.selleckchem.com/products/EX-527.html of acute urticaria in children. This was a retrospective study of 1120 children of