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In case only screening HFA (n?=?1) or Peritest visual fields (n?=?5) were available, visual impairment was defined as at least one test point with an absolute defect within the central 10�� in radius around central fixation (i.e. the WHO definition). Visual impairment in patients with only unreliable visual fields (n?=?2) was clinically judged by two authors (MJWB and PJGE) using all other available clinical data too. The cause of end-of-life http://www.selleckchem.com/products/OSI-906.html visual impairment was considered to be the first ophthalmic disorder, which permanently reduced visual acuity or the MD value. If glaucomatous damage was judged to be the cause, we subsequently analysed whether there was already substantial visual loss at the initial visit. This was defined as a visual field equal to an MD value http://www.selleckchem.com/products/ink128.html cent of all patients had their last visit in the year before http://www.selleck.cn/products/ABT-737.html they died. One hundred fifteen patients (94%) were treated with glaucoma medication and five patients (4%) underwent filtration surgery (Table?1). We divided the population into patients initially diagnosed as having OAG (i.e. group 1, n?=?61) and patients initially suspect of having glaucoma or had OHT (i.e. group 2, n?=?61). Visual fields were available from 55 patients with OAG (90%) and 42 patients with OHT or glaucoma suspects (69%). No visual fields were obtained from the remaining 25 patients because of various reasons. Advanced patient��s age and a short follow-up period were the main reasons for not performing visual field tests. Patients with at least one visual field available had a mean initial age of 70.4?years and a mean follow-up period of 10.7?years, compared with 76.6?years and 3.3?years in patients without visual fields, respectively. Eighty-nine patients had reliable standard HFA visual fields available. Because the mean number of reliable standard visual fields per eye was 2.6, a rate of visual field progression could not be estimated reliably. All 122 patients had visual acuity available for both eyes. Two eyes of two patients were totally blind at the start and three eyes of three patients were totally blind (i.e. with or without light perception) at the end of the follow-up period. None of them were caused by glaucoma.