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These data were subjected to anova with repeated measurements. Homogeneity of variances was tested by Levene��s tests. Comparisons between time points were made by linear contrasts against the baseline. No correction for multiple testing was applied. P-values below 0.05 were considered significant. As shown in Fig.?2, vaccinated patients significantly increased their IgG1 responses against each of the analyzed allergens except against Phl p 12 after one course of SCIT. The increases in IgG1 and IgG4 against Phl p 1, http://www.selleckchem.com/products/BKM-120.html Phl p 2, Phl p 5, and Phl p 6 were strong (Fig.?2A,C), whereas the increases in allergen-specific IgG2 were more moderate but nevertheless highly significant (P? http://www.selleckchem.com/products/MK-1775.html timothy grass pollen allergens Phl p 1 and Phl p 5 and for the unrelated birch pollen allergen Bet v 1. By comparing the median IgE levels in serum samples at T0 and T1, we found a reduction in the median Phl p 1-specific IgE levels in the range of 16.45% for the vaccinated group, whereas the median Phl p 1-specific IgE https://en.wikipedia.org/wiki/Oxacillin levels increased slightly in the group of patients receiving only anti-inflammatory treatment. This effect was much stronger for the highly immunogenic grass pollen allergen Phl p 5 (20). A median decrease in Phl p 5-specific IgE levels in the range of 30% was observed for the vaccinated group, whereas strong boost of Phl p 5-specific IgE of 136% was noted for the patients with only anti-inflammatory treatment. Concerning Bet v 1, the comparison of allergen-specific IgE levels at T0 and T1 showed a similar increase in median IgE levels in the vaccinated group and in patients with anti-inflammatory treatment only (i.e., SCIT group: +122%; non-SCIT group: +139%). Phl p 5-specific IgE levels in T2 were higher in both groups compared with those in T0, whereas Phl p 1-specific IgE levels in T2 were comparable with those in T0 in both groups as observed for the unrelated birch pollen allergen Bet v 1 (Fig.?3). In order to investigate the contribution of kappa and lambda chains in the vaccine-induced IgG responses, we determined allergen-specific kappa and lambda reactivities in the sera.