Treatment, Survival For Colon Cancer Differs By Race

Murphy is the study's senior author and an assistant professor in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Colon cancer is the second leading cause of cancer death in the U.S., Murphy and his colleagues write in the Journal of the National Cancer Institute. Previous studies have found black people are more likely to develop colon cancer, have more advanced cancer when diagnosed and are more likely to die of the disease than patients of other races. For the new study, the researchers used data on 9,935 white and 1,281 black patients with late-stage colon cancer from a national database. All of the patients were at least 66 years old and were diagnosed between 2000 and 2007. The study followed them until they died or through 2009. Almost three-quarters of the patients had surgery to remove tumors from their colon or rectum and 5 percent also had surgery to remove tumors that had spread to their liver or lungs. Half of the patients received chemotherapy and 13 percent received radiation. Compared to whites, black patients were 10 percent less likely to undergo surgery to remove their original tumors and 40 percent less likely to have liver or lung procedures. They were also 17 percent less likely to get chemotherapy and 30 percent less likely to get radiation. White patients lived - on average - a little more than six months after being diagnosed. That compared to less than five months among black patients. Overall, 95 percent of the patients died during the study period. But the researchers found black patients were still 15 percent more likely to die than white patients. To help determine why that was the case, the researchers tried to account for differences between the patients and their tumors. That only explained some of that 15 percent. click here to read

Colon Cancer Treatments for Metastatic Colon Cancer

Photo Credit Jupiterimages/ Images Metastatic colon cancer is cancer of the colon that has spread to the other organs. Common places for colon cancer to spread include the liver, lungs, peritoneum (the lining of the abdomen), or, in women, the ovaries, according to the American Cancer Society. Metastatic colon cancer is also known as Stage IV colon cancer. Following are some treatments for this disease. Surgery Since the colon cancer has spread to other areas other than the colon, surgery is highly unlikely to cure the metastatic cancer. To remove the primary tumor in the colon, an operation called a resection and anastomosis may be done. This procedure involves removing the tumor and some tissue surrounding the tumor, and then joining the cut parts of the colon back together. Surgery on the colon may also be done to prevent or manage a blockage in the colon. If there are small tumors on the liver or lungs, it may be possible to remove them, along with the cancer in the colon, to help prolong your life. Sometimes chemotherapy can be given before surgery, to shrink large tumors in order to better remove them. If the cancer has spread to the ovaries or other organs, parts of those organs may be removed, according to the National Cancer Institute. Radiation Therapy According to experts at the National Cancer Institute, radiation therapy is used to relieve any symptoms the metastatic colon cancer may be causing, and to improve quality of life. The radiation may shrink the tumors, and if the tumors are causing pain, the radiation will help relieve that discomfort. This is known as palliative therapy, when the goal is comfort and relief, and not cure. try these guys out

New bowel cancer treatment tests

Knowing this means they can avoid treatments which wont help but may have caused unpleasant side effects. The draft guidance has been welcomed by Bowel Cancer UK. Bowel cancer Bowel cancer, also called colorectal cancer , is the third most common cancer in the UK with around 40,000 people diagnosed with the condition each year. Bowel cancer is also the second most common cause of cancer death in the UK. Fewer than 7% of people with metastatic bowel cancer survive for longer than 5 years. Treating bowel cancer Metastatic bowel cancer means the cancer has spread from the colon or rectum to other parts of the body, such as the liver . Around half of all people diagnosed with bowel cancer have metastatic disease. Up to 60% of patients who have undergone surgery for early stage bowel cancer will eventually develop advanced disease and metastases, most often in the liver. KRAS mutation Between 35% and 40% of advanced bowel cancers have a mutation in the KRAS cancer causing gene. This makes the cancer more aggressive affecting the person's chances of surviving the cancer. Tumours with this mutation do not respond to treatment with the chemotherapy drug cetuximab. Knowing that cetuximab won't work means its toxic side effects can be avoided and other approaches taken. NHS laboratories in England already use a range of tests to identify the KRAS mutations, but there's been no agreement about which ones should be used. In draft guidance, The National Institute for Health and Care Excellence (NICE) is recommending NHS funding for: Therascreen KRAS RGQ PCR Kit (Qiagen) KRAS LightMix Kit (TIBMolBiol) Pyrosequencing of codons 12, 13 and 61 MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) mass spectrometry of codons 12, 13 and 61. additional resources