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In the HDC team, individuals also acquired HDC with HSCS. Hematological rescue con sisted of autologous hematopoietic stem cells collected from peripheral blood. After completion of treatment method, clients were evaluated at three thirty day period intervals for the first 2 a long time and at six thirty day period intervals thereafter. Evaluations integrated scientific exami nation and blood exams with CA125 evaluation. CT scan evaluations have been executed each and every six months for the first five several years and annually thereafter. Other examinations were done only when indicated. The review was authorized by our institutional evaluation board.

According to the French legislation, considering that it was a retro spective study with out biological study and with no remedy modification, no individual consent was needed. Statistical investigation Variations in affected person qualities in between the two che motherapy groups were tested by the Fishers exact check or the Pupils t take a look at. Tested parameters have been age at analysis, functionality status, FIGO stage, histological subtype, histological grade according to Silverberg classification, existence of residual ailment right after surgical procedure, presence of a clinical remission right after plati num/taxane based therapy, CA125 normalization following platinum/taxane primarily based therapy. Progression cost-free survival was calculated from the day of diagnosis till day of first condition progres sion. Overall survival was calculated from the day of diagnosis until finally date of loss of life of any cause. Adhere to up was measured from the day of diagnosis to the date of previous information for stay patients. Information relating to sufferers without having disease progression or demise at previous adhere to up had been censored. Survival curves ended up believed employing the Kaplan Meier technique, and in contrast with the log rank check.

The prognostic impact of over cited factors and chemotherapy regimen was assessed by the Cox regres sion technique the two in univariate and multivariate analysis. Multivariate analyses only included variables with p worth reduce than 5% in univariate analysis. All statistical assessments were two sided at the five% stage of significance. Sta tistical analyses were done utilizing SPSS software. Outcomes Sufferers and therapy 1 hundred sixty three patients with superior ovarian carcinomas dealt with at our institution among April 1995 and July 2009 ended up incorporated in this study. Tumor char acteristics are outlined in Desk 1. Median age at diagnosis was 54 a long time and 68% ended up more mature than fifty several years. Fifty a few percent had been grade II serous tumors. Comprehensive cytoreductive medical procedures could not be achieved for 41% of patients. Seventy per cent pre sented no scientific residual condition right after conventional therapy including surgical treatment and chemotherapy. All sufferers acquired a platinum/taxane based mostly chemother apy. Ninety per cent of individuals received carboplatin, 10% cisplatin, seventy nine% paclitaxel and 21% docetaxel.