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No statistical differences in Lmax, vasocontraction or vasorelaxation responses were observed in terms of anatomical location (axial versus inguinal) or sex (male versus female). Consequently, responses from all vessels were combined. The average unpressurized internal diameter for these feed arteries was 500 �� 200 ��m. Baseline tensions prior to KCl and PE contractile function curves were 105 �� 29 and 106 �� 33 mg, respectively. Vessel function protocols revealed robust vasocontraction (peak KCl 2009 �� 407 mg and peak PE 1974 �� 508 mg; Fig. 2A and B, respectively). Vessels were precontracted to 1460 �� 330 mg of tension prior to ACh and SNP dose�Cresponse curves, corresponding to approximately 70% of the maximal PE response, and from this point the feed artery segments achieved significant vasorelaxation (maximum SNP 102 �� 6% relaxation and maximum ACh 73 �� 10% relaxation; Fig. 2C and D, respectively). Taken together, these results indicate that the feed arteries had functional smooth muscle, ��1-adrenergic receptors and an intact endothelium. Interestingly, there was no relationship between ��1-adrenergic responsiveness, KCl-induced contraction or the ratio of these two variables and age. In the main protocol, baseline tensions were lower with a temperature of 35��C (111 �� 42 mg) or 39��C (85 �� 39 mg) in comparison with 37��C (158 �� 42 mg; P to a single dose of PE as a consequence of altering temperature from 37��C (1478 �� 338 mg) to either 35 (546 �� 104 mg) or 39��C (896 �� 202 mg; P