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1988; Travagli et al. 1992; Tache & Yang, 1993). To determine whether the responsiveness and excitability of DMV neurones was altered by perivagal CAP treatment, DMV neurones were http://www.selleckchem.com/products/GDC-0980-RG7422.html current clamped to a membrane potential that elicited a spontaneous firing rate of approximately 1 p.p.s. before superfusion with TRH (100?nm). The number of action potentials fired was counted over a 30?s period both before, during the peak response and after TRH application and expressed as a percentage of the control firing rate. TRH was applied to eight control DMV neurones; seven of these neurones responded to TRH with an increase in action potential firing rate (259?��?33% of control firing frequency; P? http://www.selleck.cn/products/PF-2341066.html These results suggest that, following perivagal CAP treatment, the ability of DMV neurones to be excited by TRH is reduced. Complete morphological properties were assessed in 18 control and 14 CAP DMV neurones and are summarized in Table 2. Perivagal CAP treatment did not alter any of the morphological features of the recorded DMV neurones (Fig. 5). Baseline motility index values were not significantly different between groups and were thus combined. The preinjection motility index value was 63?��?11, microinjection of PBS in the DVC did not induce any significant http://www.selleckchem.com/products/pembrolizumab.html effect on gastric motility (n?=?15; P?>?0.05). In five naive rats, microinjection of 100?pmol of TRH in the left DVC induced an increase in gastric motility index values from 96?��?18 to 349?��?18 (P??0.05 vs. na?ve rats) that returned to baseline values within 13.9?��?3.36?min. Three of these rats also received a microinjection of 100?pmol of TRH in the right DVC, which increased the gastric motility index values from 39?��?5 to 235?��?14 (P??0.05 vs. na?ve rats) that returned to baseline values within 17.3?��?0.31?min (Fig. 6). In five rats, which 9�C10?days earlier received pretreatment with 1% perivagal CAP, microinjection of 100?pmol of TRH in the left DVC induced a non-significant increase in gastric motility index values from 46?��?10 to 109?��?38 (P?>?0.05 vs. baseline; P?