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Based on these data adults with BAO are twice as likely to have a poor outcome as children. (��2 p http://www.selleckchem.com/products/epacadostat-incb024360.html differences in the risks and benefits of stroke therapies in children compared with adults. The goal of acute endovascular therapy in AIS is to restore perfusion to the ischemic brain by prompt recanalization of the occluded artery. Risks of hemorrhagic conversion and re-perfusion injury increase with increasing time from stroke onset. Intravenous tPA up to 4.5?hours post-onset has proven beneficial and evidence strongly supports intra-arterial tPA up to 6?hours post onset. Currently mechanical thrombolysis treatments are frequently provided in adults with acute AIS. However, the efficacy of the later approach remains unproven in adults. Increasingly, treatments in adult stroke are applied to the pediatric stroke population. This is not necessarily appropriate. It is important to http://www.selleckchem.com/products/LY294002.html consider any novel treatment including endovascular approaches in the light of age-specific risks and benefits. Given that traditional treatments are associated with much better outcomes in children than in adults, http://www.selleck.cn/products/jq1.html novel treatments justifiable in adults are less likely to be of sufficient added benefit to offset the risks. Several individual cases reports and small case series of endovascular treatment have been reported in children with acute AIS in all locations, including basilar artery thrombosis (BAT). Among 35 reported pediatric AIS cases with endovascular treatment, the mean age was 11?years (range 2�C18y); the mean time to treatment was 14?hours but ranged up to 72?hours. Eleven children received mechanical thrombolysis with or without intra-arterial tPA including four children with BAT. Overall, 29% had procedural complications (80% hemorrhagic) while complete recanalization was achieved in 35%, very similar to the rate of procedural complications. The data are even more discouraging when clinical outcomes are sought. Since arterial recanalization can cause reperfusion injury including increased cerebral hemorrhage, arterial recanalization does not itself equate to a good clinically relevant outcome.