New Technology Detects Cellular Memory, Aid In Understanding Of How Diseases Such As Cancer Arise

As only hypothesis driven approaches has been available to study the dynamic event of chromatin duplication, only few molecular factors have been linked to the process. "With our new technology, we have identified 100 new molecular components that appear to be involved in the tightly regulated process of chromatin duplication and thereby maintenance of cell memory. Thus, we provide a robust technology and the first comprehensive resource to address fundamental questions regarding maintenance of cell identity," says associate professor Anja Groth, who is heading the laboratory. Understanding the fundamental principles of how chromatin is faithfully duplicated is essential to understand how our organism is developed and maintained, and also how diseases such as cancer arise. If cells lose their chromatin memory, they can potentially develop into cancer cells and form tumours. Such a loss of what is also called 'epigenetic' memory is now known to be involved in almost all cancer types. The next step for the researchers will be to decipher the mode of action of the 100 new chromatin factors. Story Source: The above story is based on materials provided by University of Copenhagen . Note: Materials
may be edited for content and length. More information at http://www.sciencedaily.com/releases/2014/02/140224110144.htm.







New innovative technique can carry chemotherapy safely and release inside cancer cells





A major challenge in the development of light-activated drug delivery is to design a system that can respond to tissue-penetrating light. Drs. Tamanoi and Zink joined their diverse teams and collaborated with cervical cancer treatment Dr. Jean-Olivier Durand at University of Montpellier, France to develop a new type of microscopic particles (nanoparticles) that can absorb energy from tissue-penetrating light that releases drugs in cancer cells. These new nanoparticles are equipped with specially designed nanovalves that can control release of anticancer drugs from thousands of pores, or tiny tubes, which hold molecules of chemotherapy drugs within them. The ends of the cervical cancer treatment pores are blocked with capping molecules that hold the drug in like a cork in a bottle. The nanovalves contain special molecules that respond to the energy from two-photon light exposure, which opens the pores and releases the anticancer drugs. The operation of the nanoparticles was demonstrated in the laboratory using human breast cancer cells. Because the effective depth range of the two-photon laser in the infrared red wavelength can reach 4 centimeters from the skin surface, this delivery system is best for tumors that can be reached within that range, which possibly include breast, stomach, colon, and ovarian cancers. More information at http://www.news-medical.net/news/20140224/New-innovative-technique-can-carry-chemotherapy-safely-and-release-inside-cancer-cells.aspx.