Medical Advances In Crohn's Disease

Crohn's Disease Treatment

Biologic wonders. One big breakthrough in Crohns research occurred in 1998, when the first biological therapy, infliximab (Remicade), was introduced. Infliximab is an antibody that blocks tumor necrosis factor (TNF), a molecule that cells use to talk to each other; in the case of Crohns, TNF is thought to tell other cells to increase inflammation in the digestive tract. Neutralizing TNF calms the cells and restores peace in the intestines, says Dr. Braun. Three other biologic drugs have since been approved by the FDA for treating Crohns diseaseadalimumab (Humira), natalizumab (Tysabri) and the newest one, certolizumab pegol (Cimzia)and there are at least 20 others in the research pipeline. Drug combos: Strength in numbers. Can combining biologic medications with other drugs used for Crohns disease work better in controlling the disease than using either type of medication alone? Scientists have been researching that question for years and are starting to get some answers. Recent studies from Europe, Canada and the United States tested the combination of methotrexate with TNF blockers. (Methotrexate, originally developed as an anti-cancer drug, is FDA-approved for Crohns disease.) These studies found that the combination of methotrexate with TNF blockers can be more effective than either drug alone. The issue ahead is to determine ways to best define the benefit-versus-risk balance (such as a potentially greater risk of infection or cancer for an individual patient). Pop (parasite) pills. A colorful approach to treating Crohns disease is based on the fact that until improved hygiene and other health advances came into play, the human body was typically host to intestinal parasites. Rather than causing harm, these microscopic worms had a calming effect on the immune systemthe parasites way of keeping their home and food supply as healthy and accommodating as possible. Based on this knowledge, researchers at Tufts University in Medford, Mass., introduced parasites into the bodies of Crohns patients (the subjects ingested pills containing parasite eggs). his response

There are several surgical methods that may help in improving the symptoms of the condition. Aims of treatment of Crohns disease The aim of treatment of Crohns disease is to treat the active disease in order to relieve the symptoms. Maintenance therapy aims at preventing recurrence of symptoms. Medications for Crohns disease Some of the medications that are used include:- Corticosteroids Corticosteroids are hormonal medications that help in reducing the inflammation. These agents are used to treat active Crohn's disease but are not usually used for long term purposes due to their risk of side effects. Budesonide and prednisolone are the two steroid agents that are used to treat Crohns disease. Budesonide is usually the first steroid medication that is used. Another alternative is Prednisolone. Some of the side effects include acne, gastritis, swelling of face, edema, insomnia, increased vulnerability to infections, osteoporosis, cataracts, muscle cramps, depressed, mood swings etc. Steroids cannot be stopped abruptly. The dose has to be reduced gradually before stopping the drug completely. Aminosalicylates One of the agents included in this group is Sulfasalazine. This agent reduces inflammation within the colon. It may be used as an alternative to steroid medications in Crohns disease. moved here