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1998; Pires et al. 2001). For a 246 min recording period, 17 data sets of 32,768 points (27.3 min) overlapping by half were processed. The frequency resolution was therefore 0.0006 Hz. The ordinary squared coherence was calculated to quantify the strength http://www.selleckchem.com/products/Methazolastone.html of linear coupling between the left and right CBF in each group of rats. The significance threshold (P http://www.selleckchem.com/products/ABT-888.html al. 1999). We empirically set smoothing coefficients a= 25 and b= 0.5. With these values, there was no smoothing at the lowest frequency, and a smoothing over 158 contiguous frequency components at 10 Hz. All data are presented as means �� SEM. Paired and unpaired comparisons were performed using the Wilcoxon signed-rank test and the Mann�CWhitney U test, respectively. A value of P http://en.wikipedia.org/wiki/DDR1 by ?40% on the denervated (right) side at frequencies below 1 Hz (Fig. 1 and Table 2). In both intact and denervated rats, Fig. 2 shows that coherence between CBFs was significant across the whole spectrum, and was especially high at heart rate (5�C7 Hz) and Mayer waves�� (?0.4 Hz) frequencies. Coherence significantly differed between the two groups of rats in the 0.01�C0.1 Hz frequency band, where it was lower (Fig. 2) in rats with unilateral denervation (0.54 �� 0.03) compared with intact rats (0.74 �� 0.06). In both groups of rats, partialization with AP strongly reduced coherence at heart rate and Mayer waves�� frequencies, but only slightly decreased it at low frequencies (Fig. 3). In the 0.01�C0.1 Hz frequency band, this decrease reached significance (P= 0.028) in intact (0.70 �� 0.06) but not in denervated rats (0.52 �� 0.03). In this particular frequency range, the between-group difference in coherence remained essentially unaltered after partialization. The results of the present study indicate that the cerebrovascular sympathetic innervation attenuates the spontaneous variability of CBF in rats.