Irritable Bowel Syndrome: Antibiotic Shown To Relieve Common Bowel Disorder

Should I have tests for irritable bowel syndrome (IBS)?

It's also been safely used elsewhere for more than two decades. In the U.S., rifaximin is approved for traveler's diarrhea and for a complication of liver disease. Salix Pharmaceuticals, which markets rifaximin under the name Xifaxan in the U.S., is seeking to expand its use to IBS. A decision from the Food and Drug Administration is expected in March, said William Forbes, executive vice president and chief development officer for Salix. The price for IBS treatment hasn't been determined, he said. But the price listed at suggests it's not cheap, with a two-week supply of the dosage used in the study costing $910, or about $21 a pill. The two studies, reported in Thursday's New England Journal of Medicine, involved 1,260 patients who had mild to moderate irritable bowel syndrome without constipation, the most common form. Read more..

As patients' cognitive appraisal of their reality changes, their bowel symptoms often improve. Other stress management options include: Relaxation training, such as meditation, guided imagery, or biofeedback Regular exercise, including walking or yoga Breathing techniques Getting enough sleep on a regular schedule A diary may help you recognize stressors that activate symptoms. The diary should include the symptom experienced and its severity; associated factors such as diet, activity, or stress; emotional response (feelings of anger, sadness, helplessness); and thoughts associated with the incident. A record of stressors and associated responses may help you figure out positive ways to better deal with the stressors. Diet Eating causes rhythmic contractions of the colon. Normally, this may cause a person to have a bowel movement 30 to 60 minutes after a meal. In a person with IBS, the urge to defecate may come sooner and may be accompanied by pain, cramps, and diarrhea. Read more..

Synergy Pharmaceuticals Reports 2013 Fourth Quarter and Full-Year Financial Results

These tests may show that you have trouble digesting gluten (which is found in foods like bread and pasta). For more information, see the topic Celiac Disease. Imaging tests such as sigmoidoscopy, colonoscopy, or a barium enema may show problems in the colon such as inflammatory bowel disease, colon polyps, or diverticulosis. Depending on your age and history and your doctor's preferences for testing for bowel problems, these tests may be recommended at your first visit for symptoms of IBS. What can you do with the information you get from these tests? If your tests are all normal and your symptoms match the symptom criteria common in people with IBS, you may feel reassured that you do not have a serious disorder. You and your doctor can then focus on managing your symptoms so that they do not interfere with your life. Read more..

Irritable Bowel Syndrome

Brain thinning in this region was seen only in patients who listed pain as their most bothersome treatment of bowel cancer IBS symptom. Importantly, brain areas linked to anxiety and depression were no different in IBS patients than in anxious or depressed people without IBS. The findings, Seminowicz and colleagues suggest, point to a difference between IBS and chronic pain syndromes such as fibromyalgia . In chronic pain syndromes, nerves constantly send increased pain signals to the brain. But in IBS, the brain itself seems to be amplifying pain signals it receives from the bowel. The researchers say future studies should look at family members of IBS patients, to symptoms of bowel cancer see if they inherited the same brain anatomy that may increase a person's risk of IBS. Read more..

Irritable Bowel Syndrome in the Brain

Most of these adverse effects disappear over the course of time. Patients who continue to experience side effects after a few weeks of using amitriptyline should talk to their doctors. Withdrawal Syndrome Abrupt discontinuation of amitriptyline results in a withdrawal syndrome consisting of headaches, nausea, fatigue and weakness. Patients who want to discontinue amitriptyline should talk to their doctors about gradually tapering the dose. Warnings The Food and Drug Administration now requires manufacturers of antidepressants such as amitriptyline to warn potential patients about the risk of suicide. According to the FDA, people under 24 who take antidepressants for depression are more likely to commit or attempt suicide than those who do not take antidepressants. The risk probably does not apply to non-depressed patients who take antidepressants for IBS. Read more..

Amitriptyline for Irritable Bowel Syndrome

Forward-Looking Statements Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified by the use of forward-looking words such as "anticipate," "planned," "believe," "forecast," "estimated," "expected," and "intend," among others. These forward-looking statements are based on Synergy's current expectations and actual results could differ materially. There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, substantial competition; our ability to continue as a going concern; our need for additional financing; uncertainties of patent

protection and litigation; uncertainties of government or third party payer reimbursement; limited sales and marketing efforts and dependence upon third parties; and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. As with any pharmaceutical under development, there are significant risks in the development, regulatory approval and commercialization of new products. Read more..