Inflammatory Bowel Disease In Cats

All of these diseases are immune-mediated reactions of the gastrointestinal system to food, bacteria, or parasite antigens. These reactions get out of control, with large numbers of inflammatory cells collecting along the gastrointestinal tract and interfering with digestion and absorption. These syndromes can be managed but are seldom cured, and over the long term may lead to ulcers or cancer , such as lymphosarcoma. Recommended Related to Cats Urinary Tract Diseases in Cats Most urinary tract diseases are associated with a disturbance in the normal pattern of voiding. That is why it is so important to get a veterinary checkup for any cat who has been using the litter box faithfully and suddenly stops doing so. Signs include the following: Excessive urination (polyuria). Frequent voiding of normal amounts of urine suggests kidney disease. A cat compensates for a high urine output by drinking large amounts of water (polydipsia). You may notice the increased... Read the Urinary Tract Diseases in Cats article > > Other health problems, such as parasites, hyperthyroidism , and kidney disease , must be ruled out first. Blood work and ultrasound or X-ray studies of the gastrointestinal tract may be needed. The role of bacteria in these syndromes has not been clearly established in cats but has been suggested, since cats tend to have higher concentrations of bacteria in their small intestines than many other mammals. This may be related to their being obligate carnivores and having a relatively short intestinal tract. Some scientists believe that cats fed a high-protein, low-carbohydrate diet that is more like a wild cats natural diet are less likely to develop these problems. In each disease in the IBD complex, a different type of inflammatory cell (plasma cell, eosinophil, lymphocyte, macrophage) accumulates in the mucous lining of the small or large intestines. Pancreatitis and intestinal cancer may cause similar signs. this website

Explainer: what is inflammatory bowel disease?

Immunosuppressants are drugs that modify how the immune system works and generally lower its activity. Many new drugs that fall into this general class are being developed. With the immune attack reduced, the gut can often heal on its own and stay healthy for longer. Current treatment strategies generally start with older drugs but if these fail, biological therapies , such as infliximab, are tried. A biological therapy also targets the immune system. The active compounds often originate from human, animal or bacterial sources - for example, infliximab is an antibody. These drugs are effective in many people but they can have severe side-effects and become less effective over time. Three new such drugs (all using the same approach) are currently undergoing the lengthy regulatory approval process overseas. They inhibit a protein in the body called an integrin, which helps cells stick together. In inflammatory bowel disease, the integrins are what allow immune cells to invade the intestine and start the inflammatory process. The role of integrins has been known for many years, but the problem is that they are located everywhere in the body. Drugs that block all integrins are dangerous for various reasons, for example, because blood clotting is dependent on integrins. informative post