Growth Hormones Flex Little Muscle

'Hulk' protein, Grb10, controls muscle growth

Athletes take it in the belief that growth hormones will improve their performance and help them recover more quickly from injury. But they are acting on faith, because the research doesn't prove these claims, Liu says. The studies reviewed by Liu and colleagues from Californias Santa Clara Valley Medical Center and Stanford University included 303 physically fit healthy people -- mostly young men -- given growth hormone treatment either by injection or infusion. The participants were followed for one month to just under three months to determine if the growth hormone affected body composition, strength, metabolism, and exercise capacity. Although growth hormone use did seem to lead to increases in lean body mass, it did not appear to improve muscle strength. And Liu says two of three studies examining exercise performance showed growth-hormone-treated patients had higher lactate levels than untreated control subjects, which could be indicative of diminished exercise capacity. Growth-hormone-treated participants also reported more fatigue. The study appears in the May 20 issue of the Annals of Internal Medicine, but it was released online today. "More research, including identification and evaluation of the real-world growth hormone doping protocols, is warranted to definitively determine the effects of growth hormone on athletic performance," they write. Spotlight on Performance-Enhancing Drugs Like anabolic steroids, growth hormone is banned by the World- and U.S. Source -

Holt, Ph.D., a study author from the Diabetes and Obesity Research Program at the Garvan Institute of Medical Research in Sydney, Australia. "Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes ." To make this discovery, Holt and colleagues compared two groups of mice. Once group had disruption of the Grb10 gene, and were very muscular. The other group, where the Grb10 gene was functional, had normal muscles. Researchers examined the properties of the muscles in both adult and newborn mice and discovered that the alterations caused by loss of Grb10 function had mainly occurred during prenatal development . These results provide insight into how Grb10 works, suggesting that it may be possible to alter muscle growth and facilitate healing, as the processes involved in muscle regeneration and repair are similar to those for the initial formation of muscle. "Don't turn in your gym membership just yet," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal . "If you want big muscles, the classic prescription still applies: lift heavy things, eat and sleep right, and have your hormones checked. But this study shows that when we understand the basic science of how muscle fibers grow and multiply, we will be able to lift the burdenliterallyof muscle disease for many of our patients." More information: Lowenna J. Holt, Nigel Turner, Nancy Mokbel, Sophie Trefely, Timo Kanzleiter, Warren Kaplan, Christopher J. Ormandy, Roger J. Source -

New compound could reverse loss of muscle mass in cancer and other diseases

A variety of signals can activate the receptor. Prior to development of BYM338, compounds developed to block these molecules were blunt instruments, either trapping all incoming signals (which stimulated muscle growth but also caused harmful side effects) or blocking just a single receptor activator (providing only tepid growth stimulation.) BYM338 was designed to be in the Goldilocks zone (just right.) In the study the compound boosted muscle mass 25 to 50 percent and increased strength in animal models. Those gains were significantly superior to those of compounds that blocked a single receptor activator. Clinical trials are currently underway. The conditions BYM338 is designed to treat are losses of skeletal muscle and fat, which are not reversed by simply eating more, and are known as cachexias when associated with certain chronic illnesses. Cancer cachexia develops in a majority of patients with advanced malignancy, and can interfere with the ability to undergo chemotherapy, says Glass. COPD afflicts an estimated 65 million people worldwide, and is predicted to become the third leading cause of death by 2020. As many as a quarter of COPD patients suffer from cachexia, which can worsen already dire respiratory difficulties. Sarcopenia -- age-related loss of muscle and physical function -- afflicts 5-13% of 60-70 year olds, rising to 11-50% in individuals over 80 years old. Source -

muscle growth

Shop eBay! The Evolution Forum - Powered by vBulletin An adults-only forum discussing male muscle growth. ... Welcome to the The Evolution Forum. You MUST be 18 years or older to view this website. What Causes Muscle Growth? - EzineArticles Submission ... This article looks at the processes involved in building lean muscle. In order for muscles to grow, three things are required: Muscle Growth | LIVESTRONG.COM Improve your health, lifestyle, diet nutrition with Muscle Growth news, facts, tips, other information. Educate yourself about Muscle Growth help yourself and others ... Muscle Growth...How To Build Muscle And Gain Weight Quickly ... Source -

Muscle Growth: The scientific secrets to bulking up fast!

Eating any kind of carbs (other than vegetables) will spike your insulin, making fat loss all but impossible. If youre trying to get lean, youll need to limit them to the post-workout period. If youre really trying to drop fat fast, you may even want to limit your carbs to one HUGE feeding per week more of a feast or re-feed than a single meal. If mass is your main goal, however, you can add more carbs in. Pre-workout is another good time, as is breakfast. Remember, though, that the more carbs you eat the less fat youll burn. Eating them all the time may even cause a bit of fat gain, which is often necessary in building tons of muscle. (Read: Kris Gethins Body By Design workout plan ) High Reps vs Low Reps What Actually Works? Heres another age-old debate: should you lift heavy weights for low reps, or lighter weights for higher reps? Source -