Global Metastatic Colorectal Cancer Market: Latest Market Research Analysed

This report provides information on the therapeutic development for Metastatic Colorectal Cancer, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Metastatic Colorectal Cancer. Metastatic Colorectal Cancer - Pipeline Review, Half Year is built using data and information sourced from our proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by our team. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - A snapshot of the global therapeutic scenario for Metastatic Colorectal Cancer. - A review of the Metastatic Colorectal Cancer products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. - Coverage of products based on various stages of development ranging from discovery till registration stages. - A feature on pipeline projects on the basis of monotherapy and combined therapeutics. - Coverage of the Metastatic Colorectal Cancer pipeline on the basis of route of administration and molecule type. - Key discontinued pipeline projects. get more info http://www.live-pr.com/en/global-metastatic-colorectal-cancer-market-r1050286843.htm





Key link responsible for colon cancer initiation, metastasis





In the knockout mice, without CXCR2 present, the MDSC cells could no longer migrate from the circulatory system to the colon, dodge the killer CD8+ T cell immune response, and feed the blood supply of the tumor environment. Furthermore, when they transplanted normal MDSC cells (with normal CXCR2) into the knockout mice, tumor formation was restored. "These results provide the first genetic evidence that CXCR2 is required for recruitment of MDSCs into inflamed colonic mucosa and colitis-associated tumors," said DuBois. For DuBois, who has devoted his career to unraveling the inflammatory circuitry responsible for colon cancer, the results help connect the dots between the immune system, inflammation and tumor formation and metastasis. DuBois' team was the first to show that colorectal tumors contained high levels of the enzyme cyclo-oxygenase-2 (COX-2), a key step in the production of pro-inflammatory mediators such as prostaglandin E2 (PGE2). PGE2 triggers production of a CXCR2 molecule that fits into CXCR2 like a baseball into a glove's pocket and activates it. CXCR2, like the pied piper, recruits MDSCs from the bloodstream to sites of inflammation, causing the colon cancer tumors to evade the immune killer CD8+ T immune response. "Our findings reveal not only how MDSCs are recruited to local inflamed tissues and tumor microenvironment and how local MDSCs contribute to colorectal cancer progression, but now also provide a rationale for developing new therapeutic approaches to subvert chronic inflammation- and tumor-induced immunosuppression by using CXCR2 antagonists and neutralizing antibodies," said DuBois. Story Source: The above story is based on materials provided by Arizona State University . Note: Materials may be edited for content and length. Journal Reference: Hiroshi Katoh, Dingzhi Wang, Takiko Daikoku, Haiyan Sun, SudhansuK. Dey, RaymondN. DuBois. full article http://www.sciencedaily.com/releases/2013/11/131111122101.htm





Colorectal Cancer, Metastatic or Recurrent - Other Treatment



But usually other treatments are needed, such as: Radiofrequency ablation. A small wire that sends out radio waves is inserted into the tumor. The radio waves destroy the cancer that has spread to the liver without harming healthy tissue. Cryosurgery. This may be done in surgery for cancer that has spread to the liver. Liquid nitrogen is used to freeze and destroy cancer cells. Embolization. This shrinks a cancer that has spread to the liver by cutting off its blood supply. Interstitial radiation therapy. In this type of internal radiation treatment, radioactive material sealed in needles, wires, seeds, or catheters is placed directly into the tumor or body tissue. Intra-arterial hepatic chemotherapy. The surgeon implants a small pump in the belly that delivers chemotherapy right into the tumor. The pump can be left in place as long as needed. Clinical trials Clinical trials are studies that look for new treatments. If you are interested, ask your doctor if there are trials you can take part in. The National Cancer Institute or your local chapter of the American Cancer Society can also help you find clinical trials. look at these guys http://www.webmd.com/colorectal-cancer/tc/colorectal-cancer-metastatic-or-recurrent-other-treatment