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We determined the association between ratio of the diameter of the pulmonary artery to the diameter of the aorta (PA?:?A ratio) and COPD exacerbation. Follow-up CT scans were performed after one year in a subset of the cohort. A total of 142 subjects with COPD were evaluated for clinical characteristics and pulmonary artery enlargement. PA?:?A ratio was significantly associated with BMI, mMRC, and lung function. PA?:?A ratio was significantly associated with exacerbation of COPD (p?=?0.04). We measured the PA?:?A ratio on 75 subjects after one year. Mean change of the PA?:?A ratio was 0.01?��?0.06. The ratio of 34 subjects http://www.selleckchem.com/products/AZD8055.html decreased, and the ratio of 41 subjects increased. The change in PA?:?A ratio was not associated with COPD exacerbation. In conclusion, there was a significant association between pulmonary artery enlargement and COPD exacerbation in http://en.wikipedia.org/wiki/Ceramidase the COPD cohort. However, there was no association between the longitudinal change of pulmonary artery over a year with COPD exacerbation. SUNMI JU, SEUNG HUN LEE, WAN CHUL KIM, TAE WON LEE, YU JI CHO, YI YEONG JEONG, HO CHEOL KIM, JONG DEOG LEE, YOUNG SIL HWANG, SEUNG JUN LEE Division Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea Background:?The new Global Obstructive Lung Disease (GOLD) classification of Chronic Obstructive Pulmonary Disease (COPD) categorized the patients based on degree of dyspneoa, exacerbation history and severity of airflow limitation as well for treatment strategy. The utility of new ABCD classification system is unclear yet. We compared the clinical features between spirometric grades and new ABCD groups, and explored the association of clinical indexes of COPD and new ABCD classification with hospitalization for acute exacerbation of COPD (AECOPD). Methods:?We reviewed medical records of the patients with COPD (FEV1/FVC? http://www.selleckchem.com/screening/anti-cancer-compound-library.html National University Hospital from October 2011 to September 2013. The patients were classified to spirometric grades and ABCD groups, then compared of basal characteristics, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), diffusing capacity for carbon monoxide (DLCO), COPD assessment test (CAT), modified medical research council (mMRC) dyspneoa scale, six-minute walking distance (6MTD), BODE index and frequency of AECOPD including hospitalization for one year. And these indexes were analyzed as predictable factors of hospitalization for AECOPD. Results:?Of 155 patients, the distribution of patients was concentrated in GOLD 2 (45.8%) and 3 (36.8%), and group A (27.7%) and D (40.0%). MMRC was increasing from group A to D (p?