Drug Improves Remission Of Crohn Disease Among Children, Adolescents

Observational studies on thalidomide in patients with Crohn disease have reported encouraging results. Marzia Lazzerini, Ph.D., of the Institute for Maternal and Child Health, Trieste, Italy and colleagues evaluated the efficacy and adverse effects of thalidomide in inducing clinical remission in children and adolescents with refractory (not responding to treatment) Crohn disease. The study included 56 children and was conducted August 2008-September 2012 in 6 pediatric care centers in Italy. Children were randomized to thalidomide or placebo once daily for 8 weeks. The primary measured outcomes were a reduction in the Pediatric Crohn Disease Activity Index (PCDAI) score of 25 percent or 75 percent at weeks 4 and 8 (clinical remission). Nonresponders to placebo received thalidomide for an additional 8 weeks. All responders continued to receive thalidomide for an additional minimum 52 weeks. The researchers found that clinical remission was achieved by more children treated with thalidomide (13/28 [46.4 percent] vs. 3/26 [11.5 percent]). Responses were not different at 4 weeks, but greater improvement was observed at 8 weeks in the thalidomide group. Of the nonresponders to placebo who began receiving thalidomide, 11 of 21 (52.4 percent) subsequently reached remission at week 8. Overall, 31 of 49 children treated with thalidomide (63.3 percent) achieved clinical remission, and 32 of 49 (65.3 percent) achieved 75 percent response. Average duration of clinical remission in the thalidomide group was 181 weeks vs. secret info http://www.sciencedaily.com/releases/2013/11/131126191549.htm





Thalidomide May Help Kids With Crohn's Disease





Photo Credit child reading image by Ryan Shapiro from Fotolia.com Although Crohn's disease most commonly begins in adolescents and young adults between the ages of 15 and 35 according to the Crohn's and Colitis Foundation of America, it can begin at any age. The Lucile Packard Children's Hospital at Stanford reports that approximately 20 percent of Crohn's patients are children, some as young as seven. The signs and symptoms of Crohn's disease in children are similar to those seen in adults. Diarrhea Crohn's disease is one of several inflammatory bowel diseases. Crohn's disease causes inflammation in the digestive tract, also known as the gastrointestinal (GI) tract. One feature that distinguishes Crohn's disease from other IBD is that the inflammation most commonly occurs in the lower portion of the small intestine, known as the ileum, and the upper part of the colon. The inflammation of the intestines causes the cells in the intestinal walls to secrete excess water and salts. The colon usually absorbs water and minerals to be used in the body; however, when too much water and salt is flowing through the colon, it is not able to absorb it all. This causes watery, loose stools that occur frequently, known as diarrhea. The presence of persistent diarrhea is one of the characteristic symptoms, and often the first noticeable symptom, of Crohn's disease, according to the Crohn's and Colitis Foundation of America. You Might Also Like her response http://www.livestrong.com/article/100662-early-signs-crohns-disease-children/





Early Signs of Crohn's Disease in Children





Those who hadn't shown improvement while on placebo for eight weeks were switched to thalidomide for an additional eight weeks. Any of the children who responded to thalidomide therapy remained on it for at least 52 weeks, according to the study. Children or teens taking thalidomide were more likely to achieve a remission of their disease, and the remission was likely to last far longer than a remission achieved while on placebo, the study found. Side effects were infrequent. The most severe frequent side effect was a condition that causes strange sensations in the arms or legs. When someone stops taking thalidomide, the condition goes away. Thalidomide also can have a strong sedative effect, which can have less of an impact if given at night. "As it turns out, the mechanism of thalidomide is very effective for exactly the targets we're trying to treat in Crohn's, and it might be helpful for sparing kids from high steroid use," said Dr. Jonathan Ramprasad, a pediatric gastroenterologist at McLane Children's Scott &White Hospital in Temple, Texas. "But, it won't be a wonder drug. This wouldn't be a first-line treatment, or a treatment on its own. It would be used as an [additional] therapy," noted Ramprasad, who was not involved with the study. straight from the source http://www.newsday.com/news/health/thalidomide-may-help-kids-with-crohn-s-disease-1.6501798