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In future studies, a second control group with matched apnoea severity might also be included. In conclusion, our study reveals that nocturnal sleep is more disturbed in dopamine-deficient PD, and excessive daytime sleepiness is more severe in hypocretin-deficient NC. However, in PD patients, partial and progressive hypocretin signalling deficiency was also linked to EDS, as quantified with MSLT. Because of degeneration of multiple brain areas in http://www.selleckchem.com/PI3K.html PD, including probable lesions to other sleep�Cwake modulating neuronal populations, we may not conclude directly that dopamine deficiency causes primarily nocturnal sleep disruption in contrast to hypocretin deficiency, which causes hypo-arousal and EDS. This study was supported by a competitive grant from the Swiss Parkinson Foundation (http://www.parkinson.ch). None. ""Motor events during sleep can be frequently observed in patients with narcolepsy�Ccataplexy. We hypothesized that increased motor events and related arousals contribute to sleep fragmentation in this disease. We aimed to perform a detailed whole-night video-polysomnographic analysis of all motor events during non-rapid eye movement and rapid eye movement sleep in a group of narcolepsy�Ccataplexy patients and matched controls, and http://www.selleckchem.com/products/ch5424802.html to assess the association with arousals. Video-polysomnographic registrations of six narcolepsy�Ccataplexy patients and six sex- and http://www.selleck.cn/products/cb-839.html age-matched controls were analysed. Each motor event in the video was classified according to topography, number of involved body parts, duration and its association with arousals. The mean motor activity index was 59.9?��?23.0?h?1 in patients with narcolepsy�Ccataplexy compared with 15.4?��?9.2?h?1 in controls (P?=?0.004). Distribution of motor events was similar in non-rapid eye movement and rapid eye movement sleep in the patient group (P?=?0.219). In narcolepsy�Ccataplexy, motor events involved significantly more body parts (��?2 body regions: 38.2?��?15.6 versus 14.9?��?10.0; P?=?0.011). In addition, the proportion of motor events lasting longer than 1?s was higher in patients than controls (88% versus 44.4%; P?