Breast Cancer Genes Can Affect Men Too

Rise in breast cancer among men

Theresa had stage IV breast cancer and was in hospice until she passed away. When she was diagnosed, she tested positive for a BRCA gene mutation. She wanted Josh to get the blood test, too. His result was also positive. "I thought, 'Wow, I have this gene. I have to take my life a little more seriously probably,'" said Josh. For Breast cancer genes can affect men too original version, visit

Gene defects 'are cancer markers'

-Increased body weight due to unhealthy dietary habits. -Smoking and/or chronic alcoholism. -Genetic aberrations like Klinefelter Syndrome elevate estrogen levels in men. Men with a family history of breast cancer stand high risk as they may inherit either the BRCA1 or BRCA2 genes. Individuals, especially adolescents, undergoing radiation therapy for conditions like Hodgkin's Disease need to be careful as the odds of developing breast cancer are high. Symptoms A significant indicative factor is a lump in the breast. For Rise in breast cancer among men original version, visit

Among the study participants, men with one of the mutations were found to be 13 times more at risk of having high-grade T4 tumours or cancer that had spread to the lymph nodes or travelled beyond the prostate gland to other organs. Both carriers of the mutations and non-carriers were typically diagnosed at around the age of 59, and no significant association was seen with levels of PSA (prostate specific antigen), the most widely used blood marker for prostate cancer. Nor was a high Gleason score, an aggressiveness rating obtained by examining biopsy tumour samples, more common in men with the gene variants. The findings are reported in the latest edition of the British Journal of Cancer. Co-author Dr Zsofia Kote-Jarai, from the Institute of Cancer Research, said: "One of the important messages to come out of our study is that mutations to at least eight genes - and probably many more - greatly increase the risk of aggressive prostate cancer. "Any future screening programme would need to assess as many of these genes as possible - more than we currently look for in women at risk of breast cancer, for example." Dr Iain Frame, director of research at the charity Prostate Cancer UK, which part-funded the study, said: " The minefield of prostate cancer diagnosis is one of the biggest hurdles facing treatment of the disease today. For Gene defects 'are cancer markers' original version, visit

Obesity linked to increased risk of male breast cancer

An association was also seen with gynecomastia, enlarged breast tissue in men, which appeared to be separate from the effect of obesity. Klinefelter syndrome, the presence of an extra X chromosome in men, was another confirmed risk factor. Professor Anthony Swerdlow, from the Institute of Cancer Research in London, who led the UK arm of the study, said: This research brings together data from studies of male breast cancer from around the world to clarify risk factors that have been uncertain. The results suggest that men who are overweight may be at increased risk of male breast cancer. Professor Anthony Swerdlow We know that body size can be related to hormone levels. Also, hormonal factors may be the reason why patients with Klinefelter syndrome, who have comparatively low levels of testosterone and high levels of oestrogen, have raised breast cancer risks compared with other men. Our results suggest the need to investigate further the role of sex hormones in causation of breast cancer in men. Dr Matthew Lam, from the charity Breakthrough Breast Cancer, said: We know that hormonal factors play a large part in increasing risk of breast cancer in women but how these factors affect risk in men is not well understood. For Obesity linked to increased risk of male breast cancer original version, visit