Anonymous Info About Bafilomycin Made Available

The use of COCP cyclical use allows monthly menstruation, when cyclical use of COCPs does not resolve dysmenorrhoea associated with monthly bleeding (42). Oral progestogens have been used for the treatment of endometriosis and endometriosis-associated complaints for more than 40?years. Progestogens��especially non-androgenic progestogens��are well tolerated and have only few side-effects; they can be used repeatedly or continuously over a long period of time. This modality of treatment should be restricted to a group of women with pain symptoms and not wishing to conceive. As a role the pain symptoms usually relapse after cessation of treatment (43). Although, their effectiveness is well recognized, yet there are not many randomized trials to confirm that (43), (44), (45), (46)?and?(47). Medroxyprogesterone acetate was used for many years for the pain symptoms in endometriosis (48)?and?(49). In a multicentre randomized clinical study subcutaneous DMPA (104?mg/0.65?ml) was compared with leuprolide for endometriosis-associated pain. DMPA-SC 104 and leuprolide produced equivalent (P? hip and lumbar spine BMD were significantly less (P? effect on ovulation it is not a good candidate for women seeking fertility. Another problem is the uterine breakthrough bleeding which may be troublesome. Norethisterone acetate (or norethindrone acetate, NETA, 10?mg daily) is a strong progestin derivative of 19-nortestosterone. NETA was proven to be very effective in treating women with pain symptoms related to endometriosis with an overall efficacy of 94% (52). The continuous administration of norethisterone acetate to treat endometriosis is approved by the US Food and Drug Administration. Dienogest is a synthetic steroid that has been used as a progestogen in contraceptive pills and is currently being studied for its possible clinical use in the treatment of endometriosis. It exhibits highly selective binding to the progesterone receptor and has high progestational and significant antiandrogenic activity, but only moderate antigonadotrophic activity. Adverse effects associated with dienogest are the same as those expected of a progestogen. These include weight gain, increased blood pressure, breast tenderness and nausea. Dienogest was used for many years for the treatment of endometriosis (53)?and?(54). Dienogest at a dose of 2?mg daily for 12?weeks was significantly more effective than placebo for reducing endometriosis associated pain (55)?and?(56).