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The skin test was negative in all the controls. http://www.selleckchem.com/products/cx-4945-silmitasertib.html In the search for an alternative tolerated CM, in this group of 34 patients with a positive skin test, DPT was carried out selecting a CM with a negative skin test. Eleven (32.3%) cases developed 13 positive DPTs (9 to one CM and 2 to two CM). Nine cases developed a positive DPT to iodixanol and 4 to iohexol (Table?1). Figure?1 shows a positive skin test. Iomeprol (ID, 1/10) Iopramide (ID, 1/1) Iodixanol (ID, 1/10) Iohexol (ID, 1/1) Iomeprol (ID, 1/1) Ioxaglate (ID, 1/1) Iodixanol (+) Ioxaglate (?) Iomeprol (ID, 1/1) Ioxaglate (ID, 1/1) Iodixanol (+) Iobitridol (?) Iodixanol (+) Iohexol (+) Iobitridol (?) Iodixanol (+) Iohexol (?) Iodixanol (ID, 1/10) Iohexol (ID, 1/1) Iodixanol (+) Iohexol (+) Iobitridol (?) Iodixanol (ID, 1/1) Iohexol (ID, 1/1) Iomeprol (ID, 1/10) Iomeprol (ID, 1/10) Iobitridol (ID, 1/1) Iohexol (+) Iomeprol (?) A skin biopsy was taken from seven skin-test positive and DPT-positive patients (cases 5, 19, 30, 36, 55, 88 and 150) (Fig.?2), with similar results in all cases. There was a perivascular mononuclear cell infiltrate, mainly in the dermis, with higher levels of CD4 lymphocytes than CD8 T lymphocytes, with expression http://www.selleckchem.com/products/ITF2357(Givinostat).html of CD25 and a higher expression of HLA-DR and CLA. There were foci of vacuoles containing lymphocytes and in six cases accompanied by a high presence of eosinophils. In the patients with a negative skin test to all the CM tested (N?=?127), a DPT was carried out with the CM involved (Fig.?3). DPT was positive in 44 cases (34.6%), 19 to one CM and 3 to two CM. Thirty-eight cases (76%) were positive to iodixanol, 8 (16%) to iomeprol and 4 (8%) to iohexol. The response appeared at 50?cc after the first day evaluation in 69% of the episodes and in 31% https://en.wikipedia.org/wiki/Heptaminol the maximum dose (100?cc) in the second day evaluation was needed before symptoms developed. These symptoms were similar to those reported by the patients although with a lower intensity (data not shown). The time interval between drug administration and symptom development was: 1�C6?h (13 cases), 7�C12?h (27 cases), 13�C24?h (68 cases), 25�C48?h (41 cases) and >48?h (12 cases). Comparisons of this time interval showed that patients responded faster in the DPT than in the clinical history (P?