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Grand averages for each time point were then calculated. A repeated-measures ANOVA was performed on the above-mentioned data using MEP amplitude as the dependent variable, and polarity of stimulation and time course as within-subject factors. For I�CO curves, TMS intensity served as an additional within-subject factor. For significant ANOVA results, post hoc comparisons were performed using Student's t tests (paired samples, two-tailed, P? http://www.selleckchem.com/products/Adrucil(Fluorouracil).html inter-individual means were calculated for each condition. To determine significant changes, repeated measures ANOVAs were performed (ISIs, polarity of stimulation and time course as independent within-subject factors and MEP amplitude as dependent variable) (Table 2). In case of significant results of ANOVA, post hoc comparisons were performed using Student's t tests (paired samples, two-tailed, P? http://www.selleckchem.com/products/GDC-0980-RG7422.html and time course as independent within-subject factors. To exclude differences between http://www.selleck.cn/products/Nutlin-3.html baseline values of different tDCS conditions, for both single- and double-pulse protocols, we compared the respective values using Student's t tests. The Mauchly test of sphericity was performed and the Greenhouse�CGeisser correction was applied when necessary. Experiment 2 For Experiment 2, calculations were identical to those of Experiment 1, the only exception being that stimulation intensity was used as independent within-subject factor instead of polarity of stimulation. Experiment 3 For Experiment 3, calculations were identical to those of Experiment 1, the only exception being that stimulation polarity was not used as an independent within-subject factor. Subjects reported similar itchy sensations at the skin during both 2?mA cathodal and anodal trials, but these sensations were weaker during 1?mA cathodal tDCS. Baseline values of MEPs, MTs and CSPs did not differ significantly between stimulation conditions. Motor thresholds Baseline RMT was 40.1?��?8.1% (all values are reported as means?��?standard error of the mean (SEM)) of maximum stimulator output for 2?mA cathodal and 40.1?��?7.4% for 2?mA anodal stimulation; AMT was 31.4?��?7.2 and 32.8?��?7.6%, respectively.