Hi, Michk,
It may be that you need to take it a couple more days to have it kick in. Is is making you hyper at all and keeping you from getting decent sleep? Sometimes it does that to me and that, took, can add to your pain and or fatigue.

My rheumy doc. has me on a prednisone taper now; here is my drill:
I take the 5m tablets as follows: 20mg for 4 days, 15mg for 4, 10mg for 4, 5mg for 4. It usually takes 3 days to kick it for me but I'll take hydrocodone pain pills in between if it's still not working. If your prednisone doesn't kick in in a day or two, please call your rheumy doc. and let him/her know.
On ther reverse side will you please tell me if you ever took Enbrel and what you experienced and how soon after taking the Remicade did you feel relief?
Hope you feel better, michk. Take care.
Debbie

Thanks for the response, TexasDeb. I haven't been able to sleep well at all the past 2 nights (probably 3-4 hours combined), so I know that probably has something to do with it as well. If I don't feel better by tomorrow I think I'll call my doc!

About Enbrel--I never tried it. I started with Humira and went to Remicade, which worked pretty well for me.

I have been on Prednisone only for around 5 months before I began taking MTX and now on Sulfasalazine as well. I didn't go above 10 during the 5 months, but it certainly wasn't enough to stop swelling and RA symptoms, but it did take me from being a cripple to at least somewhat functioning.

I am sure your not sleeping is do the 25 mg of prednisone that you are taking. I was up to 60 mg and I described myself as the energizer bunny on crack. Before weaning down on the regimine that the doctor suggested first call him to let him know that the 25 mg doesn't seem to be working for you. He will then decide if he wants you to stay longer on the 25mg or add something he thinks can be safe while TTC to help your pain. Also, I imagine the lack of sleep coupled with your inability to get relief is upsetting and depressing you. That equals stressing and that is BAD. Try as hard as it may be to stay calm. It is especially hard when the prednisone makes you so hyper. Again, best thing to do is to call the doctor. He will know better than any of us how he wishes to proceed with you. Keep us posted sweetie! Sure hope you get some relief soon!