Multiple Sclerosis (MS) Support Group
This community is a place where members can discuss current events and weigh in on what's going on in the world.
I have been having no real ill effects from the Tysabri infusions since I started it when it came out; until the last few months. I have had excruciating headaches that nothing will touch, prescription medication won't slow it down nor will amything over the counter. Now along with the headache I have extreme diarrhea and nothing seems to slow it down. I go for a week like this before everything calms down, but by then I am worn out!
My neuro. moved to Texas, and the two neuros. in the group that are left are not really familiar with MS. As a matter of fact, the SC legislature and the Governor have signed a bill to have a committee appointed to find out why we don't have any specialists in SC for MS since we have so many MS patients.
I have to go to Atlanta or Charlotte for specialists!
Has anyone else had the same side effects with Tysabri and what did they do to relieve them?
Thanks!
KimWeat
My neuro. moved to Texas, and the two neuros. in the group that are left are not really familiar with MS. As a matter of fact, the SC legislature and the Governor have signed a bill to have a committee appointed to find out why we don't have any specialists in SC for MS since we have so many MS patients.
I have to go to Atlanta or Charlotte for specialists!
Has anyone else had the same side effects with Tysabri and what did they do to relieve them?
Thanks!
KimWeat
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I have been here before, a long long time ago and now I am back.Forgive me for not just saying what I want to say,even under a triple dose of antidepressants it is still raw and seeping and I am hesitant at revealing it as at least under the bandages around my heart I don,t have to look at how raw and wounded.My child was cleaved from my heart by his own actions. my child of ten,turning eleven...
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theatre and I are there already. I'm having a very berry tea with crackers, cheese and cherry tomatoes and she's having a joint with some beer and we're both on really comfy recliners on thick pile carpet. we need some help with the decor if anyone is around??
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Delayed Natalizumab Allergy Seen in Patient With Multiple Sclerosis
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NEW YORK (Reuters Health) Sept 26 - Although most hypersensitive reactions to natalizumab occur within hours of the first dose, such responses may be delayed, according to a case report by German researchers.
In the September issue of the Archives of Neurology, Dr. Markus Krumbholz of Ludwig Maximilian University, Munich, and colleagues report on a 23-year-old man with relapsing-remitting multiple sclerosis (MS).
Eight hours after his second infusion of natalizumab he collapsed, developed a fever, arthralgias, urticarial exanthema, and a swollen lower lip.
The patient had had no history of allergic reactions and his concomitant medication had not changed over the previous weeks. After excluding an underlying infection, the researchers treated the man with oral prednisone for 2 days. All symptoms subsequently resolved.
He tested positively for anti-natalizumab antibodies 5 weeks after his initial treatment with the agent and exhibited persistent antibody titers 8 and 12 weeks later. The researchers diagnosed a delayed allergic reaction and switched his therapy to mitoxantrone.
Thus, Dr. Krumbholz and his associates advise, "patients and treating physicians should be aware that delayed hypersensitivity reactions, such as serum sickness, can develop during treatment with natalizumab."
"If unusual symptoms consistent with an allergic reaction occur during the first days after infusion, patients should contact their neurologists to initiate appropriate medical treatment," they conclude.
Call the Biogen Tysabri 800 number I'm sorry I don't have it handy. Don't be frightened by the post which stated you had symptoms of PML. Good luck hope you feel better soon
Symptoms of PML include mental deterioration, vision loss, speech disturbances, ataxia (inability to coordinate movements), paralysis, and coma. In rare cases, seizures may occur.